Cardiovascular Effects of Experimental Exposure to Woodsmoke in Man
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Respiratory inflammation
研究概览
简要总结
Air pollution is linked to respiratory and cardiovascular disease. Wood smoke is a common air in many parts of the world and previous studies indicate that wood smoke induce oxidative stress in the respiratory tract. It is not determined how different types of biomass combustion affect human health. In this study the investigators plan to investigate how inhalation of wood smoke and pellets smoke affect respiratory and cardiovascular health.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers
排除标准
- •Use of regular medication except the oral contraceptive pill
- •Current smokers
- •Significant occupation exposure to air pollution
- •Intercurrent illness
结局指标
主要结局
Respiratory inflammation
时间窗: 24 hours after exposure to air or woodsmoke
Bronchoscopy will be performed, and samples collected by bronchoalveolar lavage and bronchial biopsy. Samples will be analysed for cell counts, histology and inflammatory markers.
次要结局
- Central arterial stiffness(Baseline and for 1 hour after exposure)
- Heart rate variability(24 hours after the exposure)
- Systemic inflammation(24 hours after the exposure)
- Lung function(Baseline and 24hrs after exposure)
研究者
Jeremy Langrish
Clinical Lecturer and Specialty Registrar in Cardiology
University of Edinburgh