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临床试验/NCT04656015
NCT04656015Unknown不适用

Cardiovascular Manifestation of Inflamatory Bowel Disease Patient ( Tissue Doppler Echocardiography and Cardiac MRI )

Assiut University0 个研究点目标入组 100 人开始时间: 2020年12月1日最近更新:
适应症

试验速览

阶段
不适用
入组人数
100
主要终点
Incidence of cardiovascular affection in IBD patients

研究概览

简要总结

  1. Evaluation of cardiovascular changes using Doppler echocardiography and cardiac MRI in IBD patients
  2. To detect the frequency of myocardial injury in IBD patients
  3. To detect the sensitivity and specificity of echocardiography for the detection of cardiac injury in comparison to cardiac MRI in IBD patients

详细描述

The burden of extra-intestinal disease is high in patients with IBD, some of whom respond to or are prevented by treating the bowel inflammation, whereas others require specific treatment because they are independent of the underlying bowel inflammation .

Cardiovascular diseases are the major causes of mortality and morbidity worldwide. They may arise for various reasons such as obesity, type 2 diabetes, genetic, environmental, dietary, and lifestyle factors. Besides all these, there is much evidence suggesting that inflammation is an important player in the pathogenesis of heart disease, as well as atherogenesis and atherosclerosis . A most common systemic inflammatory disease is inflammatory bowel disease (IBD), which is a collection of ulcerative colitis and Crohn's disease, a chronic intestinal disease that may arise due to different factors, and is precipitated by environmental and genetic susceptibility Tissue Doppler imaging (TDI) is a useful echocardiographic technique to evaluate global and regional myocardial systolic as well as diastolic function. It can also be used to quantify right ventricular and left atrial function.

To date, cardiac magnetic resonance imaging (cMRI) is mostly used to detect significantly decreased EFs and abnormalities in wall motion. Contrast enhancement (CE) CMR is a more sensitive technique of cMRI and can detect areas of myocardial damage in patients with acute myocarditis .

研究设计

研究类型
Observational
观察模型
Other
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • IBD patients presented with disease flare, which is grouped by the 3 domains of disease severity:
  • Measurable inflammatory burden (C-reactive protein, mucosal lesions, upper gastrointestinal involvement, and disease extent.
  • Disease course (including structural damage, history/extension of intestinal resection, perianal disease, number of flares, and extraintestinal manifestations)

排除标准

  • Patients with poor echocardiographic window, previously diagnosed as IHD, complete heart block, mitral stenosis, prosthetic mitral valve, congenital heart disease with a left to right shunt, and CKD patients will be excluded from the study.

结局指标

主要结局

Incidence of cardiovascular affection in IBD patients

时间窗: baseline

Incidence of cardiovascular affection in IBD patients

次要结局

  • Incidence of cardiovascular affection in IBD patients(baseline)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Mervat Sayed Kamal Sayed

resident doctor

Assiut University

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