The Effect of Non-Surgical Periodontal Treatment on Gingival Crevicular Fluid Periostin Levels in Patients With Gingivitis and Chronic Periodontitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 主要终点
- Change in periostin
研究概览
简要总结
A total of 90 subjects, 30 patients with chronic periodontitis, 30 with gingivitis and 30 periodontally healthy subjects were included. Patients with periodontal disease received non-surgical periodontal treatment. Gingival crevicular fluid periostin levels were assessed at baseline, at the 6th week and the 3rd month after treatment.
详细描述
Periostin is commonly found in collagen-rich tissues, which is thought to affect the production of collagen fibers. Additionally, periostin is synthesized in tissues exposed to constant mechanical forces such as the periosteum, periodontal ligament, tendon, heart valve and skin. Periostin mediates inflammation and fibrosis during diseases of various organs, including the heart, lung, kidney, skin, liver, skeletal muscle and retina.
This study evaluated periostin levels in gingival crevicular fluid from patients with chronic periodontitis, gingivitis and periodontally healthy as well as the effect of non-surgical periodontal treatment on gingival crevicular fluid periostin levels.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of chronic periodontitis
- •Clinical diagnosis of gingivitis
- •Clinical diagnosis of periodontal health
排除标准
- •have any systemic disease
- •to be alcohol consumer
- •to receive any periodontal therapy in the past 6 months
- •to take any drugs regularly
- •to be pregnant and/or lactate
结局指标
主要结局
Change in periostin
时间窗: Baseline, 6th week and 3rd month
Total amount of Periostin (pg/30 sec) in gingival crevicular fluid
次要结局
- Change in periodontal clinical parameter(Baseline, 6th week and 3rd month)
研究者
Ebru Olgun Erdemir
Professor
Kırıkkale University