The Endocannabinoid System in Human Gestational Tissues in Labor
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Presence of CB1 receptor protein
研究概览
简要总结
The purpose of this research study is to determine if the endocannabinoid (a biological system) plays a role in the labor process.
详细描述
This is a pilot study to determine the feasibility of identification and quantification of various components of the endocannabinoid system in the labored versus non-labored myometrium, placenta and gestational membranes.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Pregnant women ages > 18 years old
- •Pregnant women 22 weeks, 0 days through 42 weeks, 0 days gestation undergoing cesarean section
- •Singleton gestation
排除标准
- •Cannabinoid use during pregnancy
- •Illicit drug use during pregnancy
- •Nonsteroidal anti-inflammatory drug use within 7 days of cesarean section
- •Maternal comorbidities including pre-existing diabetes, pre-existing hypertension, hypertensive disorders of pregnancy (preeclampsia, eclampsia), epilepsy currently being treated with antiepileptic medication, intraamniotic infection
- •Uterine abnormalities
- •Fetal anomalies
- •Drug use or dependency
结局指标
主要结局
Presence of CB1 receptor protein
时间窗: At the time of C-section
Identification of CB1 receptor protein interacting protein (CRIP) in gestational membranes, placenta, and myometrium
Presence of cannabinoid receptor
时间窗: At the time of C-section
Identification of cannabinoid receptor interacting protein (CRIP) in gestational membranes, placenta, and myometrium
Levels of CB1 receptor protein
时间窗: At the time of C-section
Quantification of levels of CB1 receptor protein interacting protein (CRIP) in gestational membranes, placenta, and myometrium. A statistical comparison between groups will be performed.
Levels of CB2 receptor protein
时间窗: At the time of C-section
Quantification of CB2 receptor protein interacting protein (CRIP) in gestational membranes, placenta, and myometrium. A statistical comparison between groups will be performed.
Presence of CB2 receptor protein
时间窗: At the time of C-section
Identification of CB2 receptor protein interacting protein (CRIP) in gestational membranes, placenta, and myometrium
Levels of cannabinoid receptor
时间窗: At the time of C-section
Quantification of cannabinoid receptor interacting protein (CRIP) in gestational membranes, placenta, and myometrium. A statistical comparison between groups will be performed.
次要结局
未报告次要终点