Vasopressin's Effect on Behavior and Neural Activity During Social Cognition Tasks
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- Changes in neural brain activity, as observed by fMRI, when observing others during social inclusion vs. exclusion
研究概览
简要总结
It has long been established that interpersonal relationships can have a profound impact on health and well-being. Yet, the investigators are still learning about the complex biological processes that contribute to positive social interactions and the ability to develop and maintain social relationships. Recent research has begun to focus on vasopressin, a neuropeptide that is naturally produced in the hypothalamus, because administration of this neuropeptide has been associated with empathy, cooperation, memory of social stimuli (e.g., faces), and brain activity in neural regions associated with social and emotional processes. To date, several aspects of vasopressin's effects on social behavior have been unexplored. As such, the overarching goal of this project is to examine the effects of intranasal vasopressin on several tasks involving learning and social processes. In addition, the investigators will explore associated neural activity through functional magnetic resonance imaging (fMRI). Results from the study will inform our understanding of the neurobiology of socioemotional processes.
The investigators hypothesize that compared to placebo, vasopressin will improve deception detection, increase empathy and altruism, enhance responses to photo stimuli of primary caregivers, and improve learning when the subject has a prosocial goal of teaching another person. These effects will manifest in behavioral and neural activity. It is also hypothesized that main effects will not be found for vasopressin, but rather, analyses of relevant moderators will elucidate these findings.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-30 years of age
- •Healthy (see below)
- •Fluent in English
- •Right-handed
排除标准
- •Women who gave birth in the last six months, are currently pregnant, planning to become pregnant in the next 6 months, or currently breastfeeding women
- •Symptoms of runny nose due to allergies/cold or other reason
- •Current restricted fluid intake for any reason
- •Heart disease
- •Hypertension
- •History of myocardial infarction
- •History of cardiac arrhythmia
- •Kidney or liver disease
- •Vascular disease
- •Nephritis
- •Diabetes and other endocrine diseases
- •Frequent or unexplained fainting
- •History of stroke
- •Aneurysm or brain hemorrhage
- •Active psychiatric diagnosis
- •Current psychopharmacologic treatment
- •Drug or alcohol abuse
- •Medical or neurological illness
- •Regular use of medication (e.g., vasoconstrictive medications)
- •Medication intake less than 2 weeks prior to study (5 weeks for fluoxetine) including daily non-steroidal anti-inflammatory drugs
- •Smoking more than 15 cigarettes a day
- •Consumption of any alcoholic beverages in the past 24 hours will be excluded
- •Elevated blood pressure (>135/90)
- •Low blood pressure (<90/55)
- •Body temperature >100.1 F
- •Left-handed
- •Claustrophobia
- •Presence of metal in their body
研究组 & 干预措施
Intranasal vasopressin
Participants will self-administer 20 IU vasopressin (American Regent Pharmaceuticals). 5 puffs per nostril (1 puff = 2 IU vasopressin).
干预措施: Intranasal vasopressin (Drug)
Intranasal placebo
2 mls Glycerine and 3 mls purified water (methylparaben and propylparaben mixed according to purified water formula) for a total of 5 ml, which will be filtered with a 5mu filter. Participants will self-administer 5 puffs per nostril.
干预措施: Intranasal placebo (Drug)
结局指标
主要结局
Changes in neural brain activity, as observed by fMRI, when observing others during social inclusion vs. exclusion
时间窗: Between 40-115 minutes post administration
Whole brain and region of interest (ROI) regression analysis will be used to compare the neural activity of participants in the vasopressin/placebo groups. A design matrix will be created for each participant, modeling activity that is greater during the exclusion portion of the cyberball task (Williams et al., 2012) versus the inclusion portion. A first-level analysis will compare \[(friend exclusion\>friend inclusion)\>(stranger exclusion\>stranger inclusion)\] for each participant. A second-level group analysis will compare these first-level contrasts between the vasopressin and placebo groups.
次要结局
- Altruism and punishment as measured by number of points given to excluders and those excluded(Between 40-115 minutes post administration)
- Changes in neural brain activity, as observed by fMRI, when viewing images of primary caregivers versus strangers(Between 40-115 minutes post administration)
- Ratings of empathic concern after witnessing social exclusion in a friend or a stranger(Between 40-115 minutes post administration)
- Changes in brain neural activity, observed by fMRI, in response to a reading comprehension task(Between 40-90 minutes post administration)
- Performance on a memory test of reading comprehension as measured by percentage of questions answered correctly(Between 40-90 minutes post administration)
- Changes in neural brain activity, as observed by fMRI, while attempting to detect deception(Between 40-115 minutes post administration)
- Accuracy of deception detection as measured by self-report(Between 40-115 minutes post administration)
研究者
Matthew Lieberman
Matthew D. Lieberman, PhD
University of California, Los Angeles