Analysis of Nutritional Status in Patients With Malignant Tumor Diseases of the Gastrointestinal Tract
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- Prevalence of Malnutrition According to the Global Leadership Initiative on Malnutrition criteria (GLIM criteria)
研究概览
简要总结
Malnutrition and loss of muscle mass frequently occur in patients undergoing chemotherapy and can negatively effect therapy outcome. Especially patients with cancer of the gastrointestinal tract are often affected by malnutrition. Therefore, this study aims to examine changes in nutritional status of patients with cancer of the gastrointestinal tract during chemotherapy. Findings of this study will help to improve nutritional treatment of patients undergoing chemotherapy.
详细描述
Malnutrition and sarcopenia are common complications in patients with malignant diseases of the gastrointestinal tract. During chemotherapy there is a high risk of further impairment of nutritional status due to anorexia, nausea, emesis and other gastrointestinal conditions that adversely impact food assimilation or absorption. Findings on changes of nutritional status during chemotherapy are scarce but of paramount importance for adequate nutrition therapy. Therefore, this study aims to provide a detailed description of changes in nutritional status of patients with a malignant condition of the gastrointestinal tract during chemotherapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with initial diagnosis of a malignant condition of the gastrointestinal tract planned to receive cytostatic treatment.
- •ongoing cytostatic treatment of a known malignant condition of the gastrointestinal tract
排除标准
- •pregnancy
- •history of any other malignant tumor disease
- •inability to provide consent
结局指标
主要结局
Prevalence of Malnutrition According to the Global Leadership Initiative on Malnutrition criteria (GLIM criteria)
时间窗: 3 months after study enrollment
Change in prevalence of malnutrition according to the GLIM criteria
次要结局
- Hip Circumference(3 months after study enrollment)
- Energy Intake(3 months after study enrollment)
- C-reactive Protein(3 months after study enrollment)
- Plasma Transcriptome(3 months after study enrollment)
- Waist Circumference(3 months after study enrollment)
- Waist-to-Hip Ratio(3 months after study enrollment)
- Protein Intake(3 months after study enrollment)
- Carbohydrate Intake(3 months after study enrollment)
- Physical Activity(3 months after study enrollment)
- Fat Mass(3 months after study enrollment)
- Extracellular Water(3 months after study enrollment)
- Body Mass Index(3 months after study enrollment)
- Muscle Function(3 months after study enrollment)
- Dietary Fiber Intake(3 months after study enrollment)
- Gamma-glutamyl Transferase(3 months after study enrollment)
- Bilirubin(3 months after study enrollment)
- Urea(3 months after study enrollment)
- Plasma Metabolome(3 months after study enrollment)
- Prevalence of Malnutrition According to the European Society for Clinical Nutrition and Metabolism criteria (ESPEN criteria)(3 months after study enrollment)
- Fat Free Mass(3 months after study enrollment)
- Total Body Water(3 months after study enrollment)
- Phase Angle(3 months after study enrollment)
- Body Weight(3 months after study enrollment)
- Height(3 months after study enrollment)
- Sarcopenia According to the European Working Group on Sarcopenia in Older People 2 criteria (EWGSOP2 criteria)(3 months after study enrollment)
- Fat Intake(3 months after study enrollment)
- Albumin(3 months after study enrollment)
- Alanine Aminotransferase(3 months after study enrollment)
- Skeletal Muscle Mass(3 months after study enrollment)
- Upper Arm Circumference(3 months after study enrollment)
- Triceps Skinfold Thickness(3 months after study enrollment)
- Muscle Strength(3 months after study enrollment)
- Complete Blood Count(3 months after study enrollment)
- Creatinine(3 months after study enrollment)
- Intestinal Microbiome(3 months after study enrollment)
- Aspartate Transaminase(3 months after study enrollment)