Retrospective Study on Prolonged Sedation Effects With Inhaled Agents in Pediatric Intensive Care Unit
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Dosages of hypnotics first 24 hours following the introduction of halogens
研究概览
简要总结
The objective of the study is to evaluate the effects of halogenated gases on sedation and analgesia, to describe the tolerance and to determine the risk factors for failure, in pediatric intensive care patients during prolonged sedation.
This study will be based on the medical records of patients hospitalized between 2015 and 2020.
详细描述
Sedation is a major therapeutic element in patients in intensive care under artificial ventilation, in order to allow their comfort and patient-ventilator synchronization. The use of benzodiazepines in combination with opioids is common practice. However, during prolonged sedation, the effects wane, then the doses must be increased, responsible for an increase in the incidence of a significant withdrawal syndrome in the recovery phase, a source of delay in extubation or early reintubation.
The use of halogenated anesthetic gases is now possible in pediatric intensive care in these patients on artificial ventilation.
Their efficacy and tolerance in prolonged use must be evaluated. Their use could improve the sedative effects, reduce the doses of benzodiazepines and opioids used, and reduce unwanted effects in terms of withdrawal syndrome.
The objective of the study is to evaluate the effects of halogenated gases on sedation and analgesia, to describe the tolerance and to determine the risk factors for failure, in pediatric intensive care patients during prolonged sedation.
This study will be based on the medical records of patients hospitalized between 2015 and 2020.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 1 Month 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Minor patient over 1 month old (and over 36 WA of corrected age) and under 18 years old
- •Hospitalized in neonatal or pediatric intensive care unit
- •Invasive mechanical ventilation over 72 hours
- •Prolonged sedation greater than 72 hours
排除标准
- •- Opposition of the holders of parental authority of the minor patient or the adult patient to the use of the data for the study
结局指标
主要结局
Dosages of hypnotics first 24 hours following the introduction of halogens
时间窗: Day 0
Show a reduction in hypnotics dosages, calculated in Midazolam equivalent in µg / kg / h, during the first 24 hours after the introduction of halogens. A decrease will be significant if it is greater than 20% compared to the basal level before initiation of the halogens.
次要结局
- Clinical sedation score(Day 0)
- Dosages of opioids in the 24 hours following the introduction of halogens(Day 0)
- Morphinic / hypnotic dosages at the end of halogenated use(Day 0)
- Hypnotics / sedatives / curares dosages in populations of ARDS patients at the end of the use of halogens(Day 0)
- Halogenated failure criteria(Day 0)
- Tachyphylaxis to halogenated(Day 0)
- Dosages of ketamine within 24 hours of the introduction of halogens(Day 0)
- Ventilatory parameters in patients with ARDS during the period of halogen use(Day 0)
- Total duration of sedation, analgesia and curarization(Day 0)
- Withdrawal syndrome: morphine and hypnotics(Day 0)
- Adverse effects of secondary to prolonged administration of Sevoflurane or Isoflurane(Day 0)