A Comparative Evaluation Of Efficacy Of Nebulisation With Dexmedetomidine And Nebulisation With 4% Lignocaine Plus Dexmedetomidine For Awake Fibreoptic Intubation In Difficult Airway Scenario: A Randomized Control Trial
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- 1.sedation/alertness(OAA SCORE)
研究概览
简要总结
A COMPARATIVE EVALUATION OF EFFICACY OF NEBULIZATION WITH DEXMEDETOMIDINE AND NEBULIZATION WITH 4% LIGNOCAINE PLUS DEXMEDETOMIDINE FOR AWAKE FIBEROPTIC INTUBATION IN DIFFICULT AIRWAY SCENARIO
Different topical and regional techniques have been developed to subdue reflexes and facilitate awake fiberoptic intubation .It is essential to sufficiently anesthetize the upper airway and suppress the gag, swallow ,and cough reflexes prior to awake fiberoptic intubation and thus ensure patient comfort
PRIMARY OBJECTIVES:
A comparative double blinded randomised study will be performed-
- To evaluate the effect of preoperative nebulisation with dexmedetomidine and preoperative nebulisation with dexmedetomidine plus lignocaine for awake fiberoptic intubation on-
a) sedation/alertness
b) vocal cord /limb movement
c) coughing
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 20.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •patient consent, ASA grade 1 and 2, patient with anticipated difficult intubation(LEMON >2), BMI >30 kg/m2.
排除标准
- •patient refusal, airway hypersensitivity, allergy to drugs used (lignocaine/dexmedetomidine),epileptic patients,patients with poor cardiopulmonary reserve, bleeding tendency, obesity, other co-morbid conditions.
结局指标
主要结局
1.sedation/alertness(OAA SCORE)
时间窗: 0 to 5 min
2.vocal cord movement(%)
时间窗: 0 to 5 min
3.limb movement
时间窗: 0 to 5 min
4.fibreoptic intubation score
时间窗: 0 to 5 min
5.coughing
时间窗: 0 to 5 min
次要结局
- 1) To compare the hemodynamic changes of two groups(2) Dose sparing effect of propofol)