NCT04570137已完成不适用
Effects Dietary Fiber From Grains or Fruits and Vegetables on the Intestinal Production of Short-chain Fatty Acids
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 2
- 主要终点
- Short-chain fatty acids (SCFAs)
研究概览
简要总结
The aim of the study is to better understand the interplay between the intake of dietary fiber and intestinal bacteria, their metabolic activity and the effect on the intestinal barrier.
The effect of two different dietary fiber supplements is tested (arabinoxylan & ß-glucan versus inulin & fructooligosaccharides) in a randomized crossover intervention trial including healthy volunteers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 to 65 years
- •signed written informed consent
- •willingness not to change the dietary pattern in the course of the study
排除标准
- •BMI below 18 or above 30
- •acute or chronic gastrointestinal symptoms
- •neoplastic diseases
- •very strict diets, including raw foodists and frutarians
- •regular smoking (more than one box per day)
- •intake of antibiotics, immunosuppressants, or any intestinal therapeutics three months prior to study begin
- •supplementation of fibers three months prior to study begin
- •simultaneous participation in another clinical study
- •pregnancy / breastfeeding
- •relevant violations of the study protocol
- •intolerance to the fiber supplements (including wheat, oat, chicory)
- •occurrence of relevant diseases (individual decision by study physicians)
- •revocation of consent
- •placement in a clinic or similar facility based on an official or court order
结局指标
主要结局
Short-chain fatty acids (SCFAs)
时间窗: Will be measured in approx. 4 weeks after study completion.
SCFAs in native fecal samples
次要结局
- Gut microbiome composition(Will be measured in approx. 6-8 weeks after study completion.)
- Gut barrier integrity(Will be measured in approx. 4 weeks after study completion.)
研究者
Stephan C. Bischoff, MD, Professor
Prof. Dr.
University of Hohenheim
研究点 (2)
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