Exploring the Relationship Between Brain Asymmetry and Attention
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Exploratory sub-studies under this protocol will answer questions about how to optimize EEG recordings of the cortical response to TMS.
研究概览
简要总结
Background:
People tend to pay more attention to one side of space than the other and this may be due to differences in the structure and function of the two sides of the brain. We are interested in whether we can detect those difference with magnetic resonance imaging (MRI), transcranial magnetic stimulation (TMS), and electroencephalography (EEG).
Objective:
The purpose of the study is to understand how differences in brain structure may cause people to pay more attention to one side than the other.
Eligibility:
Healthy adults ages 18-35
Design:
Participants will be screened with a neurological exam.
Participants will have 2-3 visits for a total duration of about 7/8 hours.
Women of childbearing age must have a negative pregnancy test before each MRI scan.
Visits may include:
Physical exam
Tests of attention, and thinking
TMS. A brief electrical current will pass through a wire coil on the scalp. Participants will hear a click and may feel a pull. They may be asked to tense muscles or do tasks.
Magnetic resonance imaging (MRI) scan for a maximum of 1 hour. Participants will lie on a table that slides into a cylinder in a strong magnetic field. They will do tasks on a computer screen or lie still. They will get earplugs for loud noise.
EEG for no longer than 5 hours, with most lasting 3 hours. Gel and a cap with electrodes will be placed on the scalp. They will record brain waves while the participant gets TMS or does nothing.
Questions about participants dominant hand and about the MRI.
详细描述
Objective
The goal of this protocol to explore correlations between lateralized individual differences in visual attentional preference and hemispheric asymmetries in functional connectivity between the frontal and parietal visual attention areas. To measure functional connectivity, resting state functional MRI and electroencephalographic (EEG) potentials evoked with transcranial magnetic stimulation (TMS) will be used. Protocol research will also attempt to validate the TMS-evoked EEG potentials against fMRI resting state functional connectivity.
Study Population
Up to 80 right-handed and right-eyed healthy volunteers, aged 18-35
Design
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •INCLUSION CRITERIA:
- •Age 18 and older
- •Able to provide consent
- •For some sub-studies, we may limit participation by handedness or eye dominance.
排除标准
- •Any current major neurological or psychiatric disorder, such as, (but not limited to) stroke, Parkinson disease, Alzheimer disease, schizophrenia or major depression
- •Findings on neurological examination indicative of significant brain disease
- •Individuals with significant health problems, such as cardiovascular disease, malignancy, or connective tissue disorder
- •History of seizure, defined as a diagnosis by a health care provider of one or more epileptic seizures or an anecdotal history which, in the opinion of the PI, is suggestive of epileptic seizure. Any individual who answers other than negatively to the question, Have you ever had an epileptic seizure on screening will be questioned directly by the PI
- •Current oral use of a medication that lowers the seizure threshold such as neuroleptics, beta lactams, isoniazid, metronidazole, tricyclic or other antidepressants, or prescription stimulants
- •Individuals regularly taking medications that cause significant psychomotor activation or depression, e.g., stimulants and CNS depressant drugs such as benzodiazepines, will be excluded.
- •For MRI studies: Any metal in the body which would make having an MRI scan unsafe, such as pacemakers, stimulators, pumps, aneurysm clips, metallic prostheses, artificial heart valves, cochlear implants or shrapnel fragments, any individual who was a welder or metal worker. Participants will also be excluded if they are uncomfortable in small closed spaces (i.e. claustrophobia) or are not able to lie comfortably on their back for up to two hours
- •Pregnancy or plans to become pregnant in the next two months
- •Members of the Behavioral Neurology Unit, NINDS
- •Use of illegal drugs in the past year
- •Consumption of more than 7 alcoholic drinks a week for females or 14 alcoholic drinks a week for males.
- •There is no general exclusion for NIH employees. Inclusion/exclusion criteria will be checked before enrollment in each sub-study to ensure that participants remain eligible.
研究组 & 干预措施
Healthy Volunteers
thematic permission to use non-invasive techniques regarded as having minimal risk in healthy individuals, such as, MRI, EEG, EMG, low-frequency stimulation (= 1 Hz), electrical stimulation of the skin to mimic the somatosensory artifact of TMS, and behavioral tests
干预措施: TMS EEG (Device)
Healthy Volunteers
thematic permission to use non-invasive techniques regarded as having minimal risk in healthy individuals, such as, MRI, EEG, EMG, low-frequency stimulation (= 1 Hz), electrical stimulation of the skin to mimic the somatosensory artifact of TMS, and behavioral tests
干预措施: TMS fMRI (Device)
结局指标
主要结局
Exploratory sub-studies under this protocol will answer questions about how to optimize EEG recordings of the cortical response to TMS.
时间窗: 20 visits
Response to TMS
次要结局
未报告次要终点