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临床试验/NCT04682951
NCT04682951已完成不适用

Good Prognosis Factors After Decompressive Craniectomy : a Ten-year Retrospective Study

Central Hospital, Nancy, France1 个研究点 分布在 1 个国家目标入组 544 人开始时间: 2008年6月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
544
试验地点
1
主要终点
Good neurological outcome

研究概览

简要总结

Decompressive craniectomy is a treatment of refractory intracranial hypertension after various etiologies : malignant ischemic stroke, traumatic brain injury, intraparenchymal hemorrhage, aneurysmal subarachnoid hemorrhage, cerebral venous thrombosis.

Initially considered as a lifesaving therapy, benefits in terms of survival were shown compared to medical treatment alone.

However, despite a better survival, morbidity and poor neurological outcome are frequent among survivors.

The objective of the study is to identify initial good neurological outcome factors after decompressive craniectomy in a large series of patients, in order to argue surgical and intensive care decisions, considering expected benefit and quality of life.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients undergoing a decompressive craniectomy from 06/11/2008 to 06/15/2018 in CHRU Nancy, France.

排除标准

  • Infectious ou malignant disease leading to decompressive craniectomy.

结局指标

主要结局

Good neurological outcome

时间窗: 6 months after surgery

The neurological outcome is considered "good" when Glasgow Outcome Score extended (GOSE) assessed 6 months after decompressive craniectomy is between 5 and 8.

次要结局

未报告次要终点

研究者

发起方
Central Hospital, Nancy, France
申办方类型
Other
责任方
Principal Investigator
主要研究者

AUDIBERT Gérard

MD, PhD

Central Hospital, Nancy, France

研究点 (1)

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