Good Prognosis Factors After Decompressive Craniectomy : a Ten-year Retrospective Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 544
- 试验地点
- 1
- 主要终点
- Good neurological outcome
研究概览
简要总结
Decompressive craniectomy is a treatment of refractory intracranial hypertension after various etiologies : malignant ischemic stroke, traumatic brain injury, intraparenchymal hemorrhage, aneurysmal subarachnoid hemorrhage, cerebral venous thrombosis.
Initially considered as a lifesaving therapy, benefits in terms of survival were shown compared to medical treatment alone.
However, despite a better survival, morbidity and poor neurological outcome are frequent among survivors.
The objective of the study is to identify initial good neurological outcome factors after decompressive craniectomy in a large series of patients, in order to argue surgical and intensive care decisions, considering expected benefit and quality of life.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing a decompressive craniectomy from 06/11/2008 to 06/15/2018 in CHRU Nancy, France.
排除标准
- •Infectious ou malignant disease leading to decompressive craniectomy.
结局指标
主要结局
Good neurological outcome
时间窗: 6 months after surgery
The neurological outcome is considered "good" when Glasgow Outcome Score extended (GOSE) assessed 6 months after decompressive craniectomy is between 5 and 8.
次要结局
未报告次要终点
研究者
AUDIBERT Gérard
MD, PhD
Central Hospital, Nancy, France
