To study the effect of Dexmetomidine as adjuvant to 0.2 % Ropivacaine in Erector Spinae Plane block for post operative analgesia in total abdominal hysterectomies.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- The time at which patient requests for first rescue analgesic in post-operative period.
研究概览
简要总结
Total abdominal hysterectomies are associated with significantpost-operativepain**.Untreatedorpartiallytreatedpainleadstoperioperativestressresponse , adverse cardiac events , poor wound healing and delayed recovery aftersurgery.To minimize perioperative opioid use , regional anaesthesia techniquesare beingused toprovidehigh qualityanalgesia****. Theinterfascialplane blockknown as the erector spinae plane block (ESPB) involves deposition oflocalanesthetic deep to the erector spinae muscleanterior to transverse process ofvertebrae .Dexmedetomidineisanalpha2agonistwhichhassedationandanalgesicproperties.Themechanismofactionofdexmedetomidineisviaα-2A,α-2Band α-2C adrenoceptors that have shown to cause vasoconstriction which helps inprolongation of effect of local anaesthetics.It has anxiolytic , hemodynamicandcardiorespiratorystabilizing****properties**
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant, Investigator, Outcome Assessor and Date-entry Operator Blinded
入排标准
- 年龄范围
- 30.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- Female
入选标准
- •1.American Society of Anaesthesiologists (ASA) I-III 2.Adults (30 to 70 years of age) 3.Female sex
- •Total abdominal hysterectomy patients with infra umblical incision.
排除标准
- •1.Refusal for inclusion in study 2.Local anaesthetic allergy / or previous anaphylactic shock from the same 3.Infection at block site 4.Patients with history of opioid abuse
- •Patients who are unable to comprehend VAS score.
结局指标
主要结局
The time at which patient requests for first rescue analgesic in post-operative period.
时间窗: The time at which patient requests for first rescue analgesic in post-operative period in first 24 hours
次要结局
- Total opioid consumption in 24 hours(Bidirectional Visual Analogue Scale (VAS) score will be recorded at rest and on movement at designated intervals.)
研究者
Dr Udeyana Singh
Dayanand Medical College and Hospital