Comparison of Vascular Remodeling Between Different Antianginal Medication Evaluated by Noninvasive ECG-gated Fundus Photographic Evaluation
试验速览
- 阶段
- 4 期
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Wall to lumen ratio of fundus vessel
研究概览
简要总结
Treatments for stable angina includes drug therapy such as calcium-channel blocker, beta blocker, and ACEI/ARB. To obtain good prognosis in patients with coronary artery disease,preventing or correcting the progression of atherosclerosis and dyslipidemia is more important than relieving angina symptom. Dysfunction of microvessel is one of the most important factor in patients with coronary artery disease. Recently, we developed the new non-invasive method of evaluating the microvessel in fundus. With this methods, we will compare the effect of each drug (beta blocker, CCB, ARB).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 30 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Stable angina patients whose coronary lesions is confirmed by angiography or receives PCI
- •Unstable Angina/NSTEMI patients who completed PCI for main lesions
- •Either systolic > 130mmHg or diastolic > 80mmHg, or patients with anti-hypertensive drugs
排除标准
- •STEMI patients within one month
- •Variant Angina
- •Liver function abnormality or renal failure
- •History of Hypersensitivity to testing drugs
- •Severe heart failure(NYHA class>3) or uncorrectable hematologic disease
- •Woman possible to be pregnant
- •Uncontrolled diabetes
- •Expected life span < one year
研究组 & 干预措施
Candesartan treated group
Candesartan 32mg treated group
干预措施: Candesartan treated group (Drug)
Diltiazem treated group
Diltiazem 180mg treated group
干预措施: Diltiazem treated group (Drug)
Bisoprolol treated group
Bisoprolol 5mg treated group
干预措施: Bisoprolol treated group (Drug)
结局指标
主要结局
Wall to lumen ratio of fundus vessel
时间窗: baseline, 9 months
Measurement of change in the ratio of wall thickness to lumen of the fundus vessel from baseline to 9 month follow up
次要结局
- Serum markers of inflammation(baseline, 9 months)
- lipid parameter(baseline, 9 months)
- Change of nitrate need(baseline, 1 months, and 3 months)