Registry Study on "Control Nocturnal Hypertension to Reach the Target "（CONTROL-NHT）
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 4,500
- 试验地点
- 1
- 主要终点
- The occurrence time of fatal and non-fatal cardiovascular events.
研究概览
简要总结
Ambulatory blood pressure monitoring (ABPM) is a major innovation in the history of hypertension diagnosis. In clinical practice, the most well established indication for using ABPM is to identify patients who have high BP readings in the office but normal readings during usual daily activities outside of this setting or vice versa, and to identify varying 24-h BP profiles. However, in recent years, there has been increasing interest in BP values during sleep, and nocturnal BP is now recognized to be superior to daytime BP in predicting fatal and nonfatal cardiovascular events (stroke, myocardial infarction, and cardiovascular death), especially in medicated patients.
The current direction in the management of hypertension is toward earlier and lower BP control for 24 hours, including the nocturnal and morning periods. Therefore, it may be of great significance to pay attention to the management of nocturnal blood pressure so as to reduce the increased cardiovascular risks.
Information of nocturnal hypertensive patients defined by ABPM was prospectively registered nationwide, and then to investigate whether there was difference in cardiovascular prognosis according to the control of ambulatory nocturnal blood pressure.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 50-79 years old
- •Clinical diagnosed hypertension with the use of antihypertensive drugs
- •Nocturnal hypertension ( nocturnal systolic blood pressure ≥ 130 mmHg and/or nocturnal diastolic blood pressure ≥ 80 mmHg)
- •A 24-hour ambulatory blood pressure monitoring was performed with validated equipment.
- •Willing to provide information about disease history and blood biochemical test data within 6 months.
- •Sign the informed consent
排除标准
- •Without antihypertensive drug use
- •Hospitalized hypertension patients
- •Non-compliant patient
结局指标
主要结局
The occurrence time of fatal and non-fatal cardiovascular events.
时间窗: From date of enrollment until date of first documented event assessed up to 3 years
Fatal and non-fatal cardiovascular events, including cardiovascular mortality, non-fatal myocardial infarction, non-fatal stroke, coronary artery bypass grafting or interventional stenting or balloon dilation, and hospitalization for heart failure.
次要结局
- The occurrence time of fatal and nonfatal stroke.(From date of enrollment until date of first documented event assessed up to 3 years)
- The occurrence time of all-cause mortality.(From date of enrollment until date of first documented event, assessed up to 3 years)
研究者
Yan Li
Professor of Cardiovascular Medicine
Shanghai Institute of Hypertension