ACTRN12622000862741招募中3 期
Managing Delirium with FLUvoxamine treatment in Non-Cardiac Surgical patients: a feasibility trial
Royal Prince Alfred Hosptial0 个研究点目标入组 46 人开始时间: 2022年6月17日最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 发起方
- 入组人数
- 46
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Prevention
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 60 Years 至 o limit（—）
- 性别
- All
入选标准
- •Elective non-cardiac, non-intracranial surgical patients who are older than 60 years old with an expected length of hospital stay of >2 days
排除标准
- •Non-english speaking
- •Participants who may have received an investigational new drug within the last 7 days/weeks.
- •Participants who lack capacity to provide informed consent.
- •Participants with prior known intolerance/allergy to SSRIs or fluvoxamine.
- •Planned postoperative ventilation
- •Patients on medications that interact with fluvoxamine: hepatic metabolism by CYP1A2 (theophylline, clozapine, tizadine, olanzapine), metabolism inhibited by fluvoxamine (diazepam, alprazolam, phenytoin), sigma-1
- •agonists/antagonists (donepezil, sertraline), risk of serotonin syndrome (St John’s Wort, selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs)
研究者
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