Randomized controlled trail on efficacy and safety of Losartan 50 mg/HCTZ 12.5 mg and Titrated Angiotensin Receptor Blockers (ARBs) in Patients who have Hypertension with Diabetes mellitus - Study of clinical Impact of +osartan on Blood Pressure control in OSAKA II (SIMPL II)

SIMPL OSAKA Investigators0 个研究点目标入组 300 人开始时间: 2008年12月10日最近更新: 2023年10月17日

适应症

试验速览

暂无简介。

•1. Patients with IDDM 2. Patients with nephropathy (urinary albumin-to-creatinine ratio is more than 300mg/gCr). 3. Patients with poor controlled diabetes mellitus (HbA1c more than 10%) 4. Patients with insukin treatment 5. Patients with poor controlled hypertension (SBP more than 180mmHg or DBP more than 110mmHg) 6. Patients with malignant hypertension 7. Patients with critical liver damage. (ALT or AST is over 3 times of normal) 8. Patients with attack of gout 9. Patients has had any severe cardiovascular events with hospitalization within the 6 months prior to informed consent. 10. Patients is pregnant or breast feeding; or is a female expecting to conceive within the projected duration of the study. 11. Patients with the secondary hypertension. 12. Patients with non-diabetic nephropathy such as chronic glomerulonephritis. polycystic kidney disease. reniculus 13. Patients with heart failure 14. Patients has poor controlled arrhythmia. 15. Patients has treated with diuretics. 16. Patients has allergia of test drugs 17. Patients who are considered not to be negligible to the study by the investigator due to medical reasons.

发起方

SIMPL OSAKA Investigators