Impact of Canaglifloxin on Gut Hormone Secretion After Gastric Bypass
试验速览
- 阶段
- 不适用
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Difference in GLP-1 secretion (evaluated by iAUC).
研究概览
简要总结
To investigate the impact of canagliflozin on secretion of gut hormones, in particular glucagon-like peptide 1 (GLP-1) in gastric bypass operated patients.
详细描述
Glucose is a potent stimulus for GLP-1 secretion after gastric bypass surgery and the SGLT-1 transporter appears to be crucial for this response. The study will investigate the effects of SGLT-1/SGLT-2 inhibition (by canagliflozin) on secretion of GLP-1 and other gut hormones after gastric bypass surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Uncomplicated gastric bypass surgery performed minimum 12 months prior to study
排除标准
- •Type 1 or 2 diabetes mellitus prior to or after gastric bypass surgery
- •Pregnancy or breastfeeding
- •Haemoglobin levels below 6,5 mM
研究组 & 干预措施
Glucose + Canagliflozin
干预措施: Glucose + Canagliflozin (Dietary Supplement)
Glucose
干预措施: Glucose (Dietary Supplement)
结局指标
主要结局
Difference in GLP-1 secretion (evaluated by iAUC).
时间窗: 0-240 min following glucose ingestion
Comparison of the GLP-1 responses (evaluated by iAUC) between the two test days.
次要结局
- Difference in glucose responses between the two test days.(0-240 min following glucose ingestion)
- Difference in insulin responses between the two test days.(0-240 min following glucose ingestion)
- Difference in cholecystokinin (CCK) responses (evaluated by iAUC) between the two test days.(0-240 min following glucose ingestion)
- Difference in bile acid responses (evaluated by iAUC) between the two test days.(0-240 min following glucose ingestion)
- Difference in C-peptide responses between the two test days.(0-240 min following glucose ingestion)
- Difference in Gastric Inhibitory Peptide (GIP) responses (evaluated by iAUC) between the two test days.(0-240 min following glucose ingestion)
- Difference in glucagon responses (evaluated by iAUC) between the two test days.(0-240 min following glucose ingestion)
- Difference in peptide YY (PYY) responses (evaluated by iAUC) between the two test days.(0-240 min following carbohydrate ingestion)
- Difference in oxyntomodulin responses (evaluated by iAUC) between the two test days.(0-240 min following carbohydrate ingestion)
研究者
Christoffer Martinussen
Principal investigator, Medical Doctor
Hvidovre University Hospital