Effects of Carbohydrates on Gut Hormone Secretion After Gastric Bypass Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Within group difference in GLP-1 secretion (evaluated by iAUC).
研究概览
简要总结
To investigate the secretion of gut hormones, in particular glucagon-like peptide 1 (GLP-1), after ingestion of glucose and fructose as separate monosaccharides or combined in the disaccharides sucrose and isomaltulose and the effect of acarbose in gastric bypass operated subjects and BMI-matched controls.
详细描述
Disaccharides such as sucrose or isomaltulose (also called palatinose) require digestion into monosaccharides (both are digested to glucose and fructose) by enzymes located in the brush border of the small intestine to be absorbed. The study will investigate the influence of carbohydrate digestion on gut hormone secretion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •uncomplicated gastric bypass surgery performed minimum 12 months prior to study
排除标准
- •Type 1 or 2 diabetes mellitus prior to or after gastric bypass surgery
- •Pregnancy or breastfeeding
- •Haemoglobin levels below 6,5 mM
- •Healthy control subjects:
- •Exclusion Criteria:
- •Bariatric surgery or complicated upper abdominal surgery
- •Pregnancy or breastfeeding
- •Haemoglobin levels below 6,5 mM
- •Co-morbidities or medicine significantly affecting glucose metabolism or appetite regulation
研究组 & 干预措施
10 gastric bypass operated patients
4 different carbohydrate loads ingested at separate study days will be tested against each others ability to induce GLP-1 secretion.
干预措施: Glucose + Fructose (Other)
10 gastric bypass operated patients
4 different carbohydrate loads ingested at separate study days will be tested against each others ability to induce GLP-1 secretion.
干预措施: Isomaltulose (Other)
10 gastric bypass operated patients
4 different carbohydrate loads ingested at separate study days will be tested against each others ability to induce GLP-1 secretion.
干预措施: Sucrose + Acarbose (Other)
10 healthy control subjects
4 different carbohydrate loads ingested at separate study days will be tested against each others ability to induce GLP-1 secretion.
干预措施: Glucose + Fructose (Other)
10 healthy control subjects
4 different carbohydrate loads ingested at separate study days will be tested against each others ability to induce GLP-1 secretion.
干预措施: Isomaltulose (Other)
10 healthy control subjects
4 different carbohydrate loads ingested at separate study days will be tested against each others ability to induce GLP-1 secretion.
干预措施: Sucrose + Acarbose (Other)
10 healthy control subjects
4 different carbohydrate loads ingested at separate study days will be tested against each others ability to induce GLP-1 secretion.
干预措施: Sucrose (Other)
10 gastric bypass operated patients
4 different carbohydrate loads ingested at separate study days will be tested against each others ability to induce GLP-1 secretion.
干预措施: Sucrose (Other)
结局指标
主要结局
Within group difference in GLP-1 secretion (evaluated by iAUC).
时间窗: 0-240 min following carbohydrate ingestion
Comparison of the GLP-1 responses (evaluated by iAUC) induced by the different carbohydrate loads.
次要结局
- Responses (evaluated by iAUC) of Gastric Inhibitory Peptide (GIP) within and between groups.(0-240 min following carbohydrate ingestion)
- Responses (evaluated by iAUC) of cholecystokinin (CCK) within and between groups.(0-240 min following carbohydrate ingestion)
- Between group comparison of GLP-1 secretion (evaluated by iAUC).(0-240 min following carbohydrate ingestion)
- Responses (evaluated by iAUC) of insulin within and between groups.(0-240 min following carbohydrate ingestion)
- Responses (evaluated by iAUC) of C-Peptide within and between groups.(0-240 min following carbohydrate ingestion)
- Responses (evaluated by iAUC) of glucose within and between groups.(0-240 min following carbohydrate ingestion)
- Responses (evaluated by iAUC) of peptide YY (PYY) within and between groups.(0-240 min following carbohydrate ingestion)
- Responses (evaluated by iAUC) of glucagon within and between groups.(0-240 min following carbohydrate ingestion)
- Responses (evaluated by iAUC) of oxyntomodulin within and between groups.(0-240 min following carbohydrate ingestion)
- Between group comparison of differences in GLP-1 secretion (evaluated by iAUC).(0-240 min following carbohydrate ingestion)
- Responses (evaluated by iAUC) of bile acids within and between groups.(0-240 min following carbohydrate ingestion)
研究者
Christoffer Martinussen
MD
Hvidovre University Hospital