Gut Hormone Secretion and Macronutrients

Completed

• Conditions: Healthy Volunteers
• Interventions: Other: test meal; Other: glucose; Other: fat; Other: protein; Other: control

• Registration Number: NCT00869453
• Lead Sponsor: University of Lausanne

Brief Summary

The role of gut hormone (GLP-1, GIP, PYY...) in glucose homeostasis has been widely demonstrated. Furthermore modifications in their pattern of secretion seem to be involved in the improvement of glucose control in obese patients after bariatric surgery.

The purpose of this study is to assess the respective role of carbohydrate, fat and protein from a complete meal in gut hormones secretion.

Detailed Description

The study is designed to asses the role of each individual macronutrient of a compete meal in gut hormones secretion in healthy volunteers.

8 healthy young male subjects will be studied on 5 different occasions. To asses the role of each macronutient the subjects will recieve one of the following test meal: a complete sandwich, the proteic part of this complete meal, the glucidic part and the lipidic part. The fifth test will be a fasting test.

To assess the entero-insular axis, a 5.5 hours hyperglycaemic clamp will be performed.

Study Timeline

• Study Start: 2009-03
• Study First Submitted: 2009-03-25
• Study First Submitted QC: 2009-03-25
• Study First Posted: 2009-03-26
• Primary Completion: 2009-08
• Study Completion: 2009-12
• Status Verified: 2012-06
• Last Update Submitted: 2012-06-29
• Last Update Posted: 2012-07-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 8

Inclusion Criteria

• Male
• 18-35 years old
• 19 kg/m2 ≤ BMI ≤ 25 kg/m2
• Healthy
• Low to moderate physical activity
• Non smokers

Exclusion Criteria

• Family history of diabetes mellitus
• Any medication
• Participation to blood spending or other clinical study in the 3 months before the beginning of this study
• Consumption of drugs
• Consumption of more than 50g of alcool in a week
• Vegetarian or particular diet
• Anamnèse d'intolérance alimentaire
• Family history of food intolerance

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
1	control	Healthy volunteers
1	protein	Healthy volunteers
1	glucose	Healthy volunteers
1	test meal	Healthy volunteers
1	fat	Healthy volunteers

Primary Outcome Measures

Name	Time	Method
Gut hormone secretion	within 4 hours following a test meal

Secondary Outcome Measures

Name	Time	Method
Insulin sensitivity	6 hours
Glucose turnover	6 hours
Entero-insular axis measurement	within 4 hours following a test meal
Substrate oxidation	6 hours

Trial Locations

Locations (2)

Cardiomet Clinical research Center, CHUV; 🇨🇭 Lausanne, VD, Switzerland

University of Lausanne; 🇨🇭 Lausanne, Switzerland