Assessment of Fluid Responsiveness in Patients After Cardiac Surgery Comparison of Different Functional Hemodynamic Parameters and Tests
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Stroke volume increase > 15%
研究概览
简要总结
To overcome the limited accuracy of functional hemodynamic parameters such as stroke volume and pulse pressure variation (SVV and PPV) during spontaneous breathing, a Passive Leg Raising (PLR) manoeuvre has been suggested as a reliable predictor of fluid responsiveness.
Aim of this study was to evaluate fluid responsiveness using SVV, PPV and PLR during the transition from controlled to spontaneous breathing in cardiac surgery patients
详细描述
In patients after elective off-pump CABG are enrolled hemodynamic measurements are performed in the postoperative period upon arrival in the ICU using a PiCCO2 system (Pulsion Medical Systems, Munich, Germany).
Controlled fluid challenges (500 ml) are done at 3 time-points:
A) during controlled mechanical ventilation B) during pressure support ventilation with spontaneous breathing and C) after extubation.
Stroke volume (SV), SVV and PPV as well as standard hemodynamic parameters (MAP = mean arterial pressure, HR = heart rate) are assessed.
A PLR is performed before fluid administration at all 3 time points. A positive response is defined as an increase in SV>15 %.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •preserved left ventricular function
- •regular heart rhythm
排除标准
- •emergency procedures
- •intra- and extra-cardial shunts
- •aortic and tricuspid valve insufficiencies
- •peripheral arterial occlusive disease
结局指标
主要结局
Stroke volume increase > 15%
时间窗: 20 min
Stroke volume increase defines fluid responsiveness
次要结局
未报告次要终点