Methotrexate Iontophoresis Versus Coal Tar Ointement in the Treatment of Primary Palmer Hyper Hidrosis
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Assessing the change in degree of severity of hyperhidrosis
研究概览
简要总结
The purpose of the study is to compare the therapeutic effect of methotrexate iontophoresis versus coal tar ointment on the the treatment of primary palmer hyperhidrosis?
详细描述
Some researchers stated that hyperhidrosis can render the skin susceptible to infection because of the continuous dampness of the skin. The condition may become socially, psychologically and professionally debilitating.
There are a lot of literatures concerned with studying the modalities used in the treatment of primary palmar hyperhidrosis, so this study will be conducted to compare between two of them and to show the best one for treating primary palmar hyperhidrosis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 15 Years 至 35 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patient with primary palmar hyperhidrosis to extend that their palms are wet during most of the day (score 3 and 4 in the Hyperhidrosis Disease Severity Scale) was included in this study.
- •The palmer hyperhidrosis patient's age ranged from 15 to 35 years.
- •All patients will be examined by dermatologist before starting the study.
排除标准
- •The study excluded the following patients:
- •Patients with medical conditions that associated with hyperhidrosis are excluded, these conditions include:- hyperthyroidism, diabetes mellitus, parkinsonism, spinal cord injury, brain damage, congestive heart failure, anxiety, alcoholism and menopause.
- •Patients who received any treatment with a drug that was affecting sweating e.g. (thyroxin, anxiolytics.....) that is not stopped at least 4 weeks preceding the study.
- •Patients with cardiac conditions such as arrhythmia, ischemic heart disease, low exercise tolerance, low respiratory reserve were excluded.
- •Patients, who have a local wound, sever eczema and severe fungal infection of the palms to minimize risk of local burn.
- •Patients who have sensory disorders.
- •Female patients who are pregnant and lactating.
结局指标
主要结局
Assessing the change in degree of severity of hyperhidrosis
时间窗: at baseline and after 4 weeks of intervention
By using Hyperhidrosis disease severity scale. It is a (4) points scale that is used to determine the degree of severity of hyperhidrosis
Assessing the change in Sweat output
时间窗: at baseline and after 4 weeks of intervention
Sweat output was objectively measured by recording mass gained by a standard diaper of approximately 30gm that was placed in contact with palms for 10 minutes and then was weighted using laboratory mass scale
次要结局
未报告次要终点
研究者
Nayera Radwan Fathy
Principal Investigator
Cairo University