Assessment of Cerebral Metabolism, Cerebral Blood Flow and Cerebral Oxygen Damage in Patients With Cardiac Arrest Using PET-CT
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Neurologic prognosis
研究概览
简要总结
This was a single-center, observational study. Patients with successful cardiopulmonary resuscitation (CPR) will be transferred to the emergency intensive care unit for further standardized management. After successful return of spontaneous circulation (ROSC) for 72 hours and hemodynamic stability for 24 hours, the patients underwent positron emission computed tomography (PET-CT) examination after resuscitation. The supervising physician accompanied the patient and used monitors to monitor vital signs during the examination. Patients who were on ventilators were mechanically ventilated with a magnetic ventilator (HAMILTON-MRI, United States). In addition to conventional cerebral oxygen metabolism, cerebral blood flow, oxygen extraction fraction, cerebral blood volume and other indicators were added in this experiment. These indicators can evaluate the patient's cerebral metabolism, cerebral blood flow and cerebral blood oxygen damage degree. The neurological outcome was followed up 6 months after onset according to the cerebral performance category（CPC）.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age ≥18 years.
- •sustained hemodynamic stability for ≥24h.
- •the patients were unconscious and not able to obey verbal commands. • Advanced life support and target temperature management within 6 hours of return of spontaneous circulation (ROSC).
排除标准
- •Patients with hemodynamic instability.
- •Patients who could not complete cranial PET-CT examination for special reasons. • Patients during pregnancy.
- •Patients who combined traumatic brain injury, stroke, cerebral hemorrhage and other diseases.
- •Patients whose family members did not agree to be enrolled.
结局指标
主要结局
Neurologic prognosis
时间窗: 6 months
Patients will be followed up for neurologic prognosis according to the Cerebral Performance Category Scale（CPC）at 6 months after disease onset.The CPC score was divided into five grades. Grade 1 represented intact brain function, the patient was awake and alert, and had the ability to live and work normally. Grade 2 represents moderate cerebral disability, in which the person is awake and able to work part of the time in a specific environment or perform daily activities independently; Grade 3, severe cerebral disability: the person is awake but dependent on others for daily assistance and retains limited cognition; Grade 4 represents coma and vegetative state, the patient is unconscious, unconscious to the environment, and has no cognitive ability; Level 5 represents death, with the patient confirmed as brain death or death by traditional criteria. According to the CPC score, grade 1-2 was defined as good neurological outcome, and grade 3-5 was defined as poor neurological outcome.
次要结局
未报告次要终点
研究者
Tang Ziren
Professor
Capital Medical University