Brain Oxygenation During Cardiopulmonary Resuscitation - Observational Pilot Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cardiac Arrest, Out-Of-Hospital
- Sponsor
- Helsinki University Central Hospital
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Arterial oxygen partial pressure
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The study is aimed to assess (a) the incidence of hyperoxia at the point of return of spontaneous circulation (ROSC) and (b) the role of arterial blood oxygen partial pressure to brain oxygenation during out-of-hospital cardiac arrest. 80 adult patients will be recruited in a physician staffed helicopter emergency medical services. Brain regional oxygen saturation and invasive blood pressure are monitored until hospital admission and arterial blood gases are analyzed immediately when the unit arrives to the patient and again at the time of ROSC.
Investigators
Jouni Nurmi, MD
Consultant in Anaesthesia and Intensive Care Medicine
Helsinki University Central Hospital
Eligibility Criteria
Inclusion Criteria
- •out-of-hospital cardiac arrest of presumed cardiac origin
- •resuscitation will be continued at least 5 minutes (if return of spontaneous circulation not achieved earlier) after arrival of physician team
Exclusion Criteria
- •do-not-attempt-resuscitation (DNAR) order or withdrawal of treatment by prehospital critical care physician
- •return of spontaneous circulation achieved before physician-led critical team arrives
- •external cause for cardiac arrest (e.g. trauma, suffocation)
- •workload too high or environment too dangerous to perform study procedures
Outcomes
Primary Outcomes
Arterial oxygen partial pressure
Time Frame: 5-60 minutes
Arterial oxygen partial pressure at the time of return of spontaneous circulation (ROSC)
Secondary Outcomes
- Forehead regional oxygen saturation during resuscitation(0-60 minutes)