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临床试验/NCT07401927
NCT07401927已完成不适用

The Effects of Preemptive Analgesic Protocols on Perioperative Pain Management in Laparoscopic Hysterectomy: A Prospective Observational Study

Giresun University1 个研究点 分布在 1 个国家目标入组 70 人开始时间: 2026年2月2日最近更新:
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
70
试验地点
1
主要终点
Postoperative analgesia

研究概览

简要总结

The aim of this study is to evaluate the effects of ibuprofen and paracetamol administered for pre-emptive analgesia to patients undergoing laparoscopic hysterectomy on pain scores during the first 24 hours postoperatively, the amount of opioids consumed postoperatively, and adverse effects such as postoperative nausea and vomiting.

详细描述

Patients who undergo laparoscopic hysterectomy surgery are administered certain treatment methods for postoperative analgesia. These applications are a routine part of the procedure. They are medically and ethically necessary. Postoperative analgesia applications are initiated during the intraoperative process and continued during the postoperative process. The analgesia protocol to be used is determined by the patient's characteristics and the anaesthetist's experience. Multimodal analgesia protocols are scientifically accepted methods. Preemptive analgesia, a method used for pain control that reduces the severity of pain caused by analgesics, delays the initial need for analgesia, and reduces the need for painkillers, is one of these protocols. This method, applied before surgical incision or tissue damage, covers a wide range, from first-line analgesics such as paracetamol and ibuprofen to opioids and peripheral and central blocks. The aim of this study is to evaluate the effects of ibuprofen and paracetamol administered for preemptive analgesia in patients undergoing laparoscopic hysterectomy on pain scores in the first 24 hours postoperatively, the amount of opioids consumed postoperatively, and adverse effects such as postoperative nausea and vomiting.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 70 Years(Adult, Older Adult)
性别
Female
接受健康志愿者

入选标准

  • Aged 18-70
  • ASA I-III patients
  • Patients undergoing elective laparoscopic hysterectomy surgery

排除标准

  • Emergency surgery
  • Patients who require conversion to abdominal hysterectomy during the intraoperative period
  • Those with severe liver or kidney failure, a history of long-term nonsteroidal anti-inflammatory and opioid analgesic use
  • Those with a history of gastrointestinal bleeding, peptic ulcer or inflammatory bowel disease, diabetes or other neuropathic diseases
  • Patients unable to use patient-controlled analgesia (PCA) devices

研究组 & 干预措施

Group İ (İbuprofen)

Patients who are administered ibuprofen pre-emptively analgesia, in accordance with routine clinical practice.

干预措施: Ibuprofen (Drug)

Group P (Parasetamol)

Patients who are administered parasetamol pre-emptively analgesia, in accordance with routine clinical practice.

干预措施: Parasetamol (Drug)

结局指标

主要结局

Postoperative analgesia

时间窗: from the end of surgery up to 24 hours postopeartively

Postoperative analgesia was assessed by measuring postoperative pain intensity using the Visual Analog Scale (VAS) and by recording cumulative opioid or rescue analgesic consumption. The Visual Analog Scale ranges from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Lower pain scores and reduced analgesic requirements were considered indicators of better postoperative analgesia.

次要结局

  • İntraoperative analgesia(During surgery (from skin incision until the end of surgery))
  • Intraoperative hemodynamic instability(During surgery (from induction of anesthesia until the end of surgery))

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Dilek Yeniay

Anesthesiology and Reanimation physician

Giresun University

研究点 (1)

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