Optimising Vitamin D Status in Older People: A Randomised Controlled Trial of Vitamin D Supplementation

ewcastle Joint Research Office0 个研究点目标入组 379 人开始时间: 2012年8月16日最近更新: 2019年9月16日

试验速览

•Inclusion criteria as of 07/04/2017:
•1. Ambulant, community dwelling men and women aged 70 years and above (by end April2013)
•2. Individuals capable of giving informed consent on their own behalf
•3. Individuals willing to attend the Study Centre (CARU) on six occasions and to be contacted by telephone at monthly intervals between study visits over twelve months
•Original inclusion criteria:
•1. Ambulant, community dwelling men and women aged 70 years and above
•2. Individuals capable of giving informed consent on their own behalf
•3. Individuals willing to attend the Study Centre (CARU) on six occasions and to be contacted by telephone at monthly intervals between study visits over twelve months
•4. Male and female participants
•5. > 70 years old

•Exclusion criteria as of 07/04/2017:
•1. Current antiresorptive or anabolic treatment for osteoporosis
•2. Treatment with bisphosphonates for osteoporosis in past two years
•3. Current supplement use of vitamin D (>400 IU/day) or calcium (>500 mg/day) (including use of over-the-counter preparations)
•4. Fragility fracture in the previous six months
•5. Known primary hyperparathyroidism
•6. Hypercalcaemia (albumin-adjusted plasma calcium > 2.60 mmol/l)
•7. Renal impairment (Stage 4-5 Chronic Kidney Disease: eGFR < 30 ml/min/1.73m2)
•8. History of renal stones
•Original exclusion criteria:
•1. Current antiresorptive or anabolic treatment for osteoporosis.
•2. Treatment with bisphosphonates for osteoporosis in past two years.
•3. Current use of vitamin D (>400 IU/day) or calcium (>500 mg/day) (including use of over-the-counter preparations).
•4. Fragility fracture in the previous six months.
•5. Known primary hyperparathyroisism.
•6. Hypercalcaemia (albumin-adjusted plasma calcium > 2.60 mmol/l).
•7. Renal impairment (Stage 4-5 Chronic Kidney Disease: GFR < 30 ml/min/1.73m2).
•8. History of renal stones.
•9. Peanut allergy

发起方

ewcastle Joint Research Office