JPRN-UMIN000035103已完成未知
High-density Lipoprotein Cholesterol as a Therapeutic Target for Residual Risk in Patients With Acute Coronary Syndrome - High-density Lipoprotein Cholesterol as a Therapeutic Target for Residual Risk in Patients With Acute Coronary Syndrome
Department of Cardiovascular Medicine, Wakayama Medical University0 个研究点目标入组 100 人开始时间: 2018年12月2日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 100
研究概览
简要总结
o differences were observed in the baseline LDL-C and HDL-C levels between the two groups. Reduction of LDL-C levels and increase of HDL-C levels were greater in the responder group. On multivariate logistic regression analysis, LDL-C levels (OR: 0.956, 95% CI: 0.921-0.993; p=0.020) and HDL-C levels (OR: 1.143; 95% CI: 1.005-1.300, p=0.041) were independent contributors for plaque stabilization.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 20years-old 至 80years-old（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1) Target PCI lesion is graft stenosis or in-stent restenosis 2) Patients who had undergone previous PCI for the lesion under evaluation. 3) Patients who have plaque in a non-culprit site on the PCI vessel that might call for PCI during the treatment period (non-culprit lesion is unrestricted) 4) Patients already receiving lipid lowering agents (HMG-CoA reductase inhibitors [statins], fibrates, probucol, nicotinic acid, anion exchange resins, or ezetimib) 5) Patients with familial hypercholesterolemia 6) Patients with cardiogenic shock 7) Patients on cyclosporine therapy 8) Patients with liver dysfunction (ALT[GPT] >= 100IU), biliary obstruction and/or defective hepatic metabolism: acute hepatitis, acute exacerbation of chronic hepatitis, liver cirrhosis, hepatic carcinoma and/or icterus 9) Pregnant and possibly pregnant women, lactating women 10) Patients with renal dysfunction (serum creatinine >=2.0 mg/dL) or on maintenance dialysis 11) Patients who are judged by the principal or other investigator to be ineligible for enrollment in the study
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