Influence of Periodontitis and Coronary Heart Disease on Galectin-3 in Serum and Saliva
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 155
- 试验地点
- 1
- 主要终点
- Changes of Clinical Attachment Level (mm)
研究概览
简要总结
The aim of this study was to analyze the association between serum and salivary Galectin-3 levels in patients with periodontitis. Furthermore, the objective was to determine if the periodontitis influenced serum and salivary Galectin-3 levels
详细描述
Healthy controls (n=38), patients with CHD (n=39), periodontitis (n=40), and a combination of periodontitis + CHD (n=38) were enrolled in the present study. The analyzed sample undergo a demographical, clinical and periodontal evaluation and serological analyses including Endothelin-1 (ET-1) and for serum and salivary Galectin-3 levels.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Presence of at least 16 teeth
- •CP with a minimum of 40% of sites with a clinical attachment level (CAL)
- •≥2mm and probing depth (PD) ≥4mm;
- •Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs
- •Presence of ≥40% sites with bleeding on probing (BOP)
排除标准
- •Intake of contraceptives
- •Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
- •Status of pregnancy or lactation
- •Previous history of excessive drinking
- •Allergy to local anaesthetic
- •Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.
结局指标
主要结局
Changes of Clinical Attachment Level (mm)
时间窗: 1-year
Measurment of changes in Clinical Attachment Level
次要结局
未报告次要终点
研究者
Gaetano Isola, DDS, PhD
Principal Investigator
University of Messina