Effects on PaCO2 Levels of Two Different Nasal Cannula in COPD Patients With Persistent Hypercapnia Following an Acute Severe Exacerbation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Changes of the partial pressure of carbon dioxide (PaCO2) levels
研究概览
简要总结
High-flow nasal cannula (HFNC) therapy is increasingly used in the management of acute respiratory failure. Its clinical application has been expanded also in other specific settings In stable COPD patients and in those recovering from acute exacerbation, HFNC can reduce PaCO2, respiratory rate, minute ventilation and respiratory effort.
The aim of this randomized crossover physiological study is to investigate the effects on PaCO2 levels of two different nasal cannula ('Optiflow + Duet' interface vs "standard" nasal interface) in COPD patients with persistent hypercapnia following an acute severe exacerbation
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Inpatients recovering from an acute exacerbation of their disease
- •Persisting hypercapnia, despite having reached a stabilization in pH (i.e. pH>7,35 and
- •PaCO2>50 mmHg on 3 consecutive measurements)
- •Informed consent
排除标准
- •Body Mass Index (BMI) > 30 kg/m2;
- •Previous diagnosis of Obstructive sleep apnea syndrome (OSAS)
- •Chest wall disease
- •Heart failure
- •Severe hemodynamic instability ( need for amine support)
- •Acute coronary syndrome (ACS)
- •Severe arrhythmia
- •Renal insufficiency
- •Patients unable to protect respiratory airways
- •Respiratory arrest and need for endotracheal intubation
- •Pregnancy
- •Need for sedation
结局指标
主要结局
Changes of the partial pressure of carbon dioxide (PaCO2) levels
时间窗: immediately after intervention
Arterial Blood Gases will be analyzed from a sample taken from the arterial artery
次要结局
- Dyspnea score(immediately after intervention)
- Comfort(immediately after intervention)
- Transcutaneous carbon dioxide (TcPCO2) and oxygen saturation (SpO2)(90 minutes)
- Minute Ventilation (VE), (L/min)(90 minutes)
- Inspiratory effort quantification(90 minutes)
- Respiratory Rate ( RR), (b/min)(90 minutes)
- Tidal Volume ( TV), (mL)(90 minutes)
研究者
dr. Stefano Nava
Professor
IRCCS Azienda Ospedaliero-Universitaria di Bologna