Evaluation of Non-invasive Endothelial Function in Children Sickle by Vascular Ultrasound
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 31
- 试验地点
- 1
- 主要终点
- Evaluation of endothelial function
研究概览
简要总结
Sickle cell disease (SCD) is an inherited disorder characterized by recurrent painful crises with ischemia resulting from vascular occlusion. Adults with SCD have increased arterial stiffness and reduced flow-mediated dilation (FMD), due to impaired release of substances such as nitric oxide.
The present study assess the vascular properties of carotid and brachial arteries in children with SCD compared with a control group without cardiovascular risk factors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 7 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Sickle cell group :
- •Children with sickle cell syndrome (SS or SC)
- •Children hospitalized in the hematology unit (day hospital)
- •The girls set must have had a negative pregnancy test.
- •One of the two holders of parental authority must have signed consent form
- •Children affiliated to a social security scheme or equivalent
- •Control group : Children recruited in a previous study :
- •Holders of parental authority affiliated to a social security scheme
- •Children recruited during the balance of a heart murmur or a vasovagal reaction
- •Children whose cardiological examination is normal
- •Children having no cardiovascular risk factor
排除标准
- •Sickle cell group :
- •Children with intercurrent diseases such as obesity, intra uterine growth retardation (IUGR), hypertension, renal failure, infectious diseases (including HIV, Hepatitis C) or chronic inflammatory
- •Children who have sickle cell crisis there is less than 1 month.
- •Control group :
- •Children with intercurrent diseases: obesity, IUGR, hypertension, renal failure, infectious diseases (including HIV, Hepatitis C) or chronic inflammatory
研究组 & 干预措施
Sickle group
Children with major sickle cell syndrome will have an usual Echocardiography
干预措施: Echocardiography (Procedure)
Control group
Children recruited in a previous study and who had an usual Echocardiography
干预措施: Echocardiography (Procedure)
结局指标
主要结局
Evaluation of endothelial function
时间窗: baseline
Evaluation parameter of endothelial function (brachial artery): flow dependent dilatation (expressed in%)
次要结局
- match the measurement systolic and diastolic diameters(baseline)
- Match the measurement on the diastolic wall stress(baseline)
- match the measurement thickness of the intima media(baseline)
- distensibility cross sectional(baseline)