NCT01150019已完成不适用
Correlation Between Circulating Resistin and Vascular Inflammation Measured by 18FDG-PET in Obese Person
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Vascular inflammation in carotid arterial wall represented as the target-to-background ratio (TBR) using FDG-PET
研究概览
简要总结
Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis.Resistin was shown to induce vascular endothelial dysfunction and vascular smooth muscle cell proliferation.
18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between circulating resistin and vascular inflammation detected by 18FDG-PET in obese persons.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers for visiting routine medical check in our clinic
排除标准
- •History of cardiovascular disease (myocardial infarction, unstable angina,stroke, or cardiovascular revascularization)
- •Hypertension
- •Malignancy
- •Severe renal or hepatic disease
- •Subjects taking medications that might affect inflammation such as non-steroidal anti-inflammatory drugs (NSAIDs) and statin
结局指标
主要结局
Vascular inflammation in carotid arterial wall represented as the target-to-background ratio (TBR) using FDG-PET
时间窗: 12 weeks
次要结局
- Circulating serum resistin levels(12 weeks)
- Circulating serum adiponectin levels(12 weeks)
- carotid intima-media thickness levels measured using ultrasonography(12 weeks)
研究者
研究点 (1)
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