Normal Echocardiographic Parameters of Indian Population and Comparison With the ASE Reference Range
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 150
- 试验地点
- 2
- 主要终点
- ESIVST
研究概览
简要总结
Echocardiography forms one of the most used modality in the evaluation of cardiac anatomy and functions in both patients with cardiac symptoms and in healthy individuals for occupational and research purpose. The interpretation of any medical investigation including echocardiographic report is based on its comparison with the normal range for that parameter, which is known to vary depending on the age, sex, body surface area (BSA), ethnicity and race. Since most of the medical/surgical treatment decisions are made based on the echocardiographic reports, the interpretation of results should be accurate. Even though there are many studies defining reference ranges of echocardiographic parameters, most of them were based on studies conducted in Western and European population, who shows considerable difference in their anthropometric measurements from the Indian population. Hence for the accurate diagnosis of any cardiac abnormalities, the reference values should have been derived from studies conducted in population of that particular race and ethnicity who are free of risk factors for the cardiac disease. Hence the investigator planned to conduct a study to determine the normal Echocardiographic parameters and compare it with the reference range of established by American society of echocardiography (ASE).
详细描述
Aim To determine the mean and standard deviation for Echocardiographic 2 dimensional, Doppler and strain parameters in Indian population and compare it with the reference range established by ASE
Materials and Methods After getting ethical clearance and informed patient consent, the study will be performed in 150 individuals who visit pre-anaesthetic check up (PAC) clinic for minor surgery which includes plastic, rhino-otolaryngeal, ophthalmologic, orthopaedic, abdominal, urological, gynaecological surgeries, who are free of cardiac disease or any known risk factors for the cardiac disease like chronic alcoholism, chronic smoking, metabolic syndrome, morbid obesity. The duration of study will be from October 2017 to June 2018 or till 150 individual studied.
Echocardiographic Study For all the individual electrocardiogram (ECG) integrated TTE will be done using general electric (GE) Echocardiographic machine using the cardiac probe of frequency 5 Hz in supine or left lateral position in a comfortable environment. All images will be recorded as per the ASE recommendations and the images will be analysed by echo cardiographer accredited by the national board of echocardiography. Three consecutive cardiac cycles were measured and average of the three will be taken for analysis.
Image acquisition By placing the Transducer in the left third or fourth intercostal space adjacent to the sternum parasternal short axis (PSAX) view is obtained, by tilting the probe superiorly and inferiorly, the true short axis view of the LV where both the papillary muscle are seen. Parasternal long axis (PLAX) view is formed by rotating the probe perpendicular from the true PSAX view. By applying M mode across the tip of the MV in PLAX view the end diastolic, end systolic dimensions of LV, posterior wall and inter-ventricular septum thickness, relative wall thickness (RWT) and LV internal dimension will be measured from leading edge to leading edge.1 From the same image FS, LVEF by Teicholtz method, LV mass by linear cube method will be calculated.
LV EF (Teicholtz)32 :
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age between18 to 60 years
排除标准
- •History of congenital or acquired cardiac abnormality
- •Symptoms and Signs suggestive of any cardio-respiratory disease
- •Systemic hypertension SBP more than 140 and DBP more than90
- •Known case of Diabetes mellitus or signs and symptoms suggesting like polyuria, polydipsia, autonomic dysfunction
- •History of long term exercise
- •Systemic disease like chronic kidney disease, chronic liver disease, chronic obstructive pulmonary disease
- •LVH or any abnormality in ECG
- •Abnormal chest X-ray
- •Obesity defined by BMI MORE THAN 25 kg/m2)
研究组 & 干预措施
TRANSTHORACIC ECHOCARDIOGRAM
Individuals who visit pre-anaesthetic check up (PAC) clinic for minor surgery which includes plastic, rhino-otolaryngeal, ophthalmologic, orthopaedic, abdominal, urological, gynaecological surgeries, who are free of cardiac disease or any known risk factors for the cardiac disease like chronic alcoholism, chronic smoking, metabolic syndrome, morbid obesity
干预措施: DOING TRANSTHORACIC ECHOCARDIOGRAM (Other)
结局指标
主要结局
ESIVST
时间窗: up to 30 minutes
End systole inter-ventricular septum thickness
RV FAC
时间窗: up to 30 minutes
Right ventricle fractional area change
EDIVST
时间窗: up to 30 minutes
End diastole inter-ventricular septum thickness
ESLVID
时间窗: up to 30 minutes
End systole left ventricle internal diameter
EDPWT
时间窗: up to 30 minutes
End diastole posterior wall thickness
Mitral tricuspid aortic pulmonary annulus diameter
时间窗: up to 30 minutes
Mitral tricuspid aortic pulmonary annulus diameter
EDLVID
时间窗: up to 30 minutes
End diastole left ventricle internal diameter
LV strain
时间窗: up to 30 minutes
Left ventricle strain
TAPSE
时间窗: up to 30 minutes
Tricuspid annular plane systolic excursion
Mitral and tricuspid E',A', S'
时间窗: up to 30 minutes
Mitral and tricuspid annular tissue velocities
RVOT diameter
时间窗: up to 30 minutes
Right ventricle outflow tract diameter
ESPWT
时间窗: up to 30 minutes
End systole posterior wall thickness
LVEF
时间窗: up to 30 minutes
Left ventricle ejection fraction
RV TEI index
时间窗: up to 30 minutes
Right ventricle TEI index
次要结局
未报告次要终点
研究者
Ganesh Kumar Munirathinam
Principal Investigator
Post Graduate Institute of Medical Education and Research, Chandigarh