Investigating the Effect of Neuromuscular Electrical Stimulation and Blood Flow Restriction Training on Physiological Deconditioning During Unloading and Retraining
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 36
- 主要终点
- Change in maximal isometric strength via Biodex Dynamometer
研究概览
简要总结
Following injury or surgery to a limb, it is often immobilised to allow tissue healing. Short periods of disuse cause loss of muscle size and strength and impaired mechanical properties of tendons, which leads to reduced function. Strategies to combat these deconditioning adaptations include neuromuscular electrical stimulation (NMES), however at present its effectiveness is limited. Recent research suggests that the effects of NMES can be augmented with blood flow restriction (BFR). At present, the effect of combining these two techniques on muscle function during limb immobilisation is unknown. Furthermore, the impact of BFR training during retraining following immobilisation is unknown.
详细描述
Following injury or surgery to a limb, it is often immobilised to allow tissue healing. Short periods of disuse cause loss of muscle size and strength and impaired mechanical properties of tendons, which leads to reduced function. Strategies to combat these deconditioning adaptations include neuromuscular electrical stimulation (NMES), however at present its effectiveness is limited. Recent research suggests that the effects of NMES can be augmented with blood flow restriction (BFR). At present, the effect of combining these two techniques on muscle function during limb immobilisation is unknown. Furthermore, the impact of BFR training during retraining following immobilisation is unknown.
This study will examine the effectiveness and feasibility of a neuromuscular electrical stimulation and blood flow restriction protocol during a 7 day period of immobilisation. Multiple measures across several physiological systems will be obtained.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Between the age of 18-55
- •Non-smoker
- •No previous history of cardiovascular, respiratory or neurological problems
- •Not taking anticoagulant medication
- •Injury-free in the 3 months prior to scheduled participation in the study.
排除标准
- •Hypertension (<140/80)
- •Metal work in-situ
- •Blood diseases or clotting issues
- •Injury or previous injury (<3 months prior to scheduled participation in the study)
- •Pregnancy
结局指标
主要结局
Change in maximal isometric strength via Biodex Dynamometer
时间窗: Through study completion, an average of 1 year
Strength measure
Change in maximal isokinetic strength via Biodex Dynamometer
时间窗: Through study completion, an average of 1 year
Strength measure
次要结局
- Change in muscle VO2 via near-infrared spectroscopy(Through study completion, an average of 1 year)
- Change in blood markers via venous blood samples(Through study completion, an average of 1 year)
- Change in muscle endurance via Biodex Dynamometer(Through study completion, an average of 1 year)
- Change in muscle morphology via 2D and 3D ultrasonography(Through study completion, an average of 1 year)
- Change in pressure pain thresholds via handheld allometry(Through study completion, an average of 1 year)
- Change in corticomotor excitability and inhibition, via transcranial magnetic stimulation(Through study completion, an average of 1 year)