NCT01513486已完成不适用
The Effects of Daily Neuromuscular Electrical Stimulation on Muscle Mass During Short-term One-legged Knee Immobilization in Healthy Young Men
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- muscle mass, muscle fiber size
研究概览
简要总结
In the present study, the effects of 5 days of lower limb immobilization with or without daily neuromuscular electrical stimulation on muscle mass and muscle fiber characteristics will be determined.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Aged from 18-35 years
- •18.5 < BMI < 30 kg/m2
排除标准
- •Performing regular resistance training in the previous 6 months
- •Hypertension (according to WHO criteria) [46] and/or cardiovascular disease
- •Any back/leg/knee/shoulder complaints which may interfere with the use of crutches
- •Use of any prescribed medication
- •Type 2 diabetes mellitus
- •Any family history of thrombosis
- •All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis).
- •Myocardial infarction within the last 3 years
- •Use of anti-coagulants
结局指标
主要结局
muscle mass, muscle fiber size
时间窗: three days before immobilization, and directly after immobilization (day of cast removal; day 6)
次要结局
- muscle strength measured by quadriceps 1-Repetition Maximum by Leg Extension(three days before immobilization, and directly after immobilization (day of cast removal; day 6))
研究者
Lex Verdijk
Assistant Professor
Maastricht University Medical Center
研究点 (1)
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