The effects of daily neuromuscular electrical stimulation on muscle mass during long-term unilateral ankle immobilization in adults with ankle fractures

Completed

• Conditions: Muscle metabolism; Disuse atrophy; 10037008; 10028302

• Registration Number: NL-OMON40701
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

- Unilateral closed ankle fracture (Weber type A, B or C)
- Aged from 18-65 years
- BMI above 18.5 and below 30 kg/m2
- Undergoing surgical treatment

Exclusion Criteria

- Additional fractures beside ankle fracture (e.g. multi-trauma following a car accident)
- Use of oral anticoagulants such as vitamin K-antagonists (e.g. acenocoumarol and fenprocoumon) and direct-acting or new oral anticoagulants (e.g. apixaban, dabigatran and rivaroxaban)
- Any family history of thrombosis
- All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis)
- Myocardial infarction within the last 3 years

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Calf muscle (gastrocnemius) cross sectional area (CSA). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Type I and II muscle fiber CSA and SC content, intramuscular triglyceride<br /><br>content and mRNA and protein expression of anabolic signaling proteins.</p><br>