A comparative study of two different doses of Magnesium Sulphate in attenuation of stress response in laryngoscopy and tracheal intubation
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- To study hemodynamic and stress response in laryngoscopy and tracheal intubation
研究概览
简要总结
This study is performed to compare the different doses of magnesium sulphate in attenuation of stress response in laryngoscopy and tracheal intubation . MgSO4 inhibits catecholamine release and acts on hemodynamic stability as a pre medication. It also have intraoperative as well as post operative analgesia through various mechanisms. Many individual studies are conducted for use of systemic MgSO4 indifferent doses .Very few studies are available on the effects of different doses of MgSO4 in attenuation of stress response during laryngoscopy and tracheal intubation. We are planning to conduct a study to compare the effect of different doses of MgSO4 in attenuation of stress response during laryngoscopy and tracheal intubation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients willing to participate in study 2)Patients willing to sign written & informed consent 3)Patients belonging to American Society of Anesthesiologists (ASA) physical status I and II.
- •Patients posted for elective laparoscopy surgeries under general anesthesia.
排除标准
- •Patient with ASA Grade III or IV 2)Serum Magnesium level more than 2.5mg/dl 3)Pregnant and lactating female 4)Patient with neuromuscular disorder.
结局指标
主要结局
To study hemodynamic and stress response in laryngoscopy and tracheal intubation
时间窗: preoperative | peri operative | At 1min | At 3min | At 5min | At 7min | At 10min | At 15min | At 30min | At 45min | At 60min | At 75min | At 90min | post operative: | 1hr | 2hr | 4hr | 6hr | 12hr | 24hr
次要结局
- To compare the efficacy of different doses of MgSO4 in attenuation of stress response(Hemodynamic response will be compared in both the groups at premedication time, immediate post intubation, 5,10.30,60,120 min)
研究者
Neelam Kumari Labana
Smt.Bhikiben Kanjibhai Shah Medical Institute and research centre