Association of Serum Connective Tissue Growth Factor (CTGF/CCN2) Levels With Pain and Functional Status in Patients With Chronic Plantar Fasciitis
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 60
- 主要终点
- Serum CTGF/CCN2 Level
研究概览
简要总结
This observational study aims to evaluate serum Connective Tissue Growth Factor (CTGF/CCN2) levels in patients with chronic plantar fasciitis compared with asymptomatic controls. The study will also assess the associations between serum CTGF levels and clinical and ultrasonographic characteristics of chronic plantar fasciitis.
详细描述
This is a single-center observational study including patients with chronic plantar fasciitis and asymptomatic controls. Serum CTGF/CCN2 levels will be evaluated, and their associations with clinical and ultrasonographic characteristics will be assessed.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-65 years.
- •Written informed consent.
- •For the patient group: chronic plantar heel pain for at least 3 months, pain during the first steps in the morning or after prolonged rest, tenderness over the medial calcaneal tubercle, and clinical and ultrasonographic findings consistent with chronic plantar fasciitis.
- •For the control group: asymptomatic individuals without a previous diagnosis or clinical and ultrasonographic findings of plantar fasciitis.
排除标准
- •Tarsal tunnel syndrome, calcaneal stress fracture, plantar fascia rupture, Achilles tendinopathy, heel fat pad syndrome, plantar fibromatosis, or other foot conditions causing plantar heel pain.
- •Diabetes mellitus.
- •Inflammatory rheumatic diseases or gout.
- •Chronic kidney or liver disease.
- •Malignancy.
- •Active infection or autoimmune disease
- •Pregnancy.
- •Previous foot or ankle surgery.
- •Corticosteroid injection, platelet-rich plasma (PRP), prolotherapy, extracorporeal shock wave therapy (ESWT), or other interventional treatment to the affected heel within the previous 3 months.
- •Serious systemic conditions that may affect serum CTGF/CCN2 levels.
研究组 & 干预措施
Chronic Plantar Fasciitis Group
Patients with chronic plantar fasciitis diagnosed based on clinical and ultrasonographic evaluation.
Control Group
Asymptomatic participants without clinical or ultrasonographic findings of plantar fasciitis.
结局指标
主要结局
Serum CTGF/CCN2 Level
时间窗: At baseline
Serum Connective Tissue Growth Factor (CTGF/CCN2) levels will be measured in patients with chronic plantar fasciitis and asymptomatic controls.
次要结局
- Pain Severity(At baseline)
- Foot Function Index(At baseline)
- Plantar Fascia Thickness(At baseline)
研究者
Zeynep Karakuzu Güngör
Physical Medicine and Rehabilitation Specialist
Kanuni Sultan Suleyman Training and Research Hospital