Serum D-dimer and procalcitonin levels atadmission as predictors of severity in acute pancreatitis: an observationalstudy

This prospective observational cohort study aims to assessthe predictive value of serum D-dimer and procalcitonin levels at admission indetermining the severity of acute pancreatitis (AP). The study will includeadult patients (18–70 years) presenting within 24 hours of symptom onset. TheRevised Atlanta Classification and Modified Marshall Scoring System will beused to classify AP severity and assess organ dysfunction. Given the associationsof AP with systemic inflammation, sepsis, and microvascular thrombosis,procalcitonin and D-dimer levels may serve as early biomarkers for severityassessment. A total of 62 patients will be recruited, accounting for a 10%dropout rate. Blood samples will be collected at admission for D-dimer andprocalcitonin measurements. Patients will be monitored for up to 8 days oruntil discharge for development of complications, organ failure, and outcomes.Data will be analysed using SPSS, with ROC curve analysis to evaluate thepredictive accuracy of both biomarkers. Multiple regression will identifyindependent predictors of severity and mortality. The study seeks to establishwhether these biomarkers can aid in early risk stratification and guideclinical decision-making in acute pancreatitis.