Targeted Decision Making In Renal Cell Carcinoma Relying on a Radiogenomics Translational Platform
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- accuracy of multiparametric preoperative MRI
研究概览
简要总结
This project aims to provide an accurate strategy to guide the decision making relying on tumor biopsies using standard histology, immunohistochemistry (IHC), spatial transcriptomics, genomics combined with Magnetic Resonance Imaging (MRI) and radiomics. Moreover, the investigators will explore potential markers indicative of response to systemic agents or ablative therapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Presence of a renal mass up to 4 cm
- •Adult > 18 years
- •Candidate to renal surgery
- •Informed consent signed
排除标准
- •Contraindication for MRI
结局指标
主要结局
accuracy of multiparametric preoperative MRI
时间窗: At final pathological assessment , at least 1 month after surgery
Detection of "Unfavourable outcome" is defined as the presence of at least one of the following pathological characteristics: * High grade tumor (G3 or G4) * Not-organ confined disease (pT3 and or pT4 and/or LNI) * Sarcomatoid features
次要结局
未报告次要终点
研究者
Umberto Capitanio
Group Leader Renal Cancer Lab
IRCCS San Raffaele