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临床试验/NCT03997149
NCT03997149已完成不适用

Stress-induced Eating Behavior: Implications for Pediatric Obesity Disparities

University of Michigan2 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2013年12月12日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
60
试验地点
2
主要终点
Food consumption

研究概览

简要总结

The goal of this study was to examine the glucocorticoid and behavioral responses to a psychological stressor in obese African-American and non-Latino white adolescents. Participants were exposed to the Trier Social Stress Test (TSST) and a control condition on separate days. Immediately following each condition, participants were provided with snacks to eat at their leisure. Reactivity was assessed via salivary cortisol and alpha-amylase area under the curve (AUC), and adolescents were categorized as high or low reactors.

详细描述

In the United States, pediatric obesity has more than tripled in the last 30 years, particularly among certain racial/ethnic groups including African-Americans. This disparity is partially attributable to greater exposure to psychological stress reported in this group (relative to non-Latino whites). Chronic psychological stress leads to weight gain directly through prolonged exposure to biological stress mediators such as cortisol and indirectly through behavioral pathways involving cortisol-induced increases in food consumption. An exciting arena of scientific advancements is focusing on identifying the specific pathways through which chronic stress influences eating behavior with emerging evidence to suggest that food intake, which is commonly increased during periods of stress, may serve as one key mechanism linking stress and obesity, particularly in African-American youth who are disproportionately exposed to chronic stress and have greater access to, and consumption of, energy-dense palatable foods. It is critical to advance understanding of the interplay between stress and food intake in understanding racial/ethnic disparities in pediatric obesity because stress eating represents a modifiable health behavior. That is, increased food intake during periods of elevated stress can be targeted for intervention in ways that may ameliorate the deleterious effects of stress on obesity risk. This project investigated the role of stress eating as a pathway linking chronic stress and obesity in African-American and non-Latino white adolescents.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Single Group
主要目的
Diagnostic
盲法
Single (Participant)

盲法说明

Immediately following each condition, participants were provided with snacks to eat at their leisure. Participants were not told that their post-condition food consumption would be measured and was part of the research study.

入排标准

年龄范围
14 Years 至 19 Years(Child, Adult)
性别
All
接受健康志愿者

入选标准

  • Overweight and obese adolescents ages 14- 19 years

排除标准

  • Currently pregnant
  • Had been enrolled in a weight loss program in the last 6 months
  • Were current smokers (e.g., tobacco, marijuana, vaping)
  • Were diagnosed with a mental health condition (e.g, depression)
  • Were diagnosed with a chronic condition known to affect weight, appetite, blood glucose or insulin levels (e.g., diabetes)
  • Were taking medications known to affect metabolic processes (e.g., growth hormone, ritalin, metformin, etc)
  • Had food allergies, intolerances, or other dietary restrictions

研究组 & 干预措施

Stress Condition

Experimental

The stress condition involved the Trier Social Stress Test (TSST), a standardized laboratory stressor designed to elicit psychological stress and cortisol responses. Following the TSST, participants were brought to a separate room, instructed to rest and given the option to eat at their leisure. Books and magazines were included in the room for the participant to utilize.

干预措施: Acute Laboratory Stressor (Behavioral)

Rest Condition

Placebo Comparator

Participants completed a control condition on a separate day. This condition followed the same sequence of events as the stress condition with the exception that the 20-minute TSST was replaced with a 20-minute low-affect educational film screening.

干预措施: Low affect video (Behavioral)

结局指标

主要结局

Food consumption

时间窗: 2 hours

Change in grams of each food consumed during the control and stress conditions were recorded and calories were calculated using the corresponding nutritional labels.

次要结局

  • Salivary cortisol area under the curve(2 hours)
  • Salivary alpha amylase area under the curve(2 hours)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Rebecca Hasson

Director, Childhood Disparities Research Laboratory

University of Michigan

研究点 (2)

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