Postprandial Response to Emotion-Diet Interactions in Pregnancy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 113
- 试验地点
- 4
- 主要终点
- Postprandial Glycemic Response With Stress Exposure
研究概览
简要总结
This study will investigate how maternal emotional state following a controlled stress exposure in pregnancy influences blood glucose and insulin levels after eating a standardized meal, and whether the effects of emotional state on blood glucose and insulin is different after eating a healthy meal (low GI) compared to a less healthy meal (high GI).
详细描述
Maternal glucose-insulin homeostasis in pregnancy represents one of the most important physiological processes for maternal and child health outcomes. Although maternal diet is a key regulator of this process, its effects vary widely across individuals. Maternal stress could represent a moderator of considerable importance in this regard, yet little is known about the effects of stress on glycemic control in pregnancy and whether the effects of stress may vary as a function of diet quality. This project will investigate the effects of acute psychosocial stress exposure on the postprandial metabolic response to a meal of varying glycemic index (GI) among women with overweight/obesity in mid-pregnancy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •English and/or Spanish speaking
- •18-22 week's gestation
- •Pre-pregnancy BMI 25.0-39.9 kg/m2
- •Singleton, intrauterine pregnancy
- •Non-smoker
- •Non-diabetic and normal result on a random peripheral blood glucose test at the screening visit (<200 mg/dl)
排除标准
- •Non-fluency in English or Spanish
- •BMI <25.0 or ≥40.0 kg/m2
- •>22 week's gestation
- •multiple pregnancy
- •current smoker
- •present/prior obstetric conditions (preeclampsia, infections, placental abnormalities, uterine anomalies, congenital malformations, fetal chromosomal abnormalities)
- •presence of any conditions that may dysregulate neuroendocrine, metabolic or cardiovascular function, such as diabetes, hepatic, renal, or autoimmune disorders
- •current psychiatric disorders or undergoing treatment/taking psychiatric medications
- •use of systemic/frequent corticosteroids or thyroid, lipid-lowering or anti-diabetic medications
- •gestational diabetes mellitus or raised glucose result detected on the screening visit
- •unwilling to eat the standard breakfast meal at each laboratory visit
结局指标
主要结局
Postprandial Glycemic Response With Stress Exposure
时间窗: 2 weeks
Glycemic response (area-under-the-curve of glucose) to the assigned meal type during the visit with the psychosocial stress task (TSST)
Postprandial Glycemic Response Without Stress Exposure
时间窗: 2 weeks
Glycemic response (glucose area-under-the-curve) to the assigned meal type during the visit with the non-stress control condition
Postprandial Glycemic Response With Stress Exposure
时间窗: 2 weeks
Glycemic response (area-under-the-curve of glucose) to the assigned meal type during the visit with the psychosocial stress task (TSST)
Postprandial Glycemic Response Without Stress Exposure
时间窗: 2 weeks
Glycemic response (glucose area-under-the-curve) to the assigned meal type during the visit with the non-stress control condition
次要结局
- Postprandial Insulin Response With Stress Exposure(2 weeks)
- Postprandial Insulin Response Without Stress Exposure(2 weeks)
- Postprandial Insulin Response With Stress Exposure(2 weeks)
- Postprandial Insulin Response Without Stress Exposure(2 weeks)
研究者
Karen Lindsay
Assistant Professor
University of California, Irvine