Emotion-Diet Interactions in Pregnancy
- Conditions
- Emotional StressStress, PsychologicalGlucose Intolerance During PregnancyInsulin Sensitivity/ResistancePregnancy RelatedPostprandial Hyperglycemia
- Registration Number
- NCT04430439
- Lead Sponsor
- University of California, Irvine
- Brief Summary
This study will investigate how maternal emotional state following a controlled stress exposure in pregnancy influences blood glucose and insulin levels after eating a standardized meal, and whether the effects of emotional state on blood glucose and insulin is different after eating a healthy meal (low GI) compared to a less healthy meal (high GI).
- Detailed Description
Maternal glucose-insulin homeostasis in pregnancy represents one of the most important physiological processes for maternal and child health outcomes. Although maternal diet is a key regulator of this process, its effects vary widely across individuals. Maternal stress could represent a moderator of considerable importance in this regard, yet little is known about the effects of stress on glycemic control in pregnancy and whether the effects of stress may vary as a function of diet quality. This project will investigate the effects of acute psychosocial stress exposure on the postprandial metabolic response to a meal of varying glycemic index (GI) among women with overweight/obesity in mid-pregnancy.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 113
- English and/or Spanish speaking
- 18-22 week's gestation
- Pre-pregnancy BMI 25.0-39.9 kg/m2
- Singleton, intrauterine pregnancy
- Non-smoker
- Non-diabetic and normal result on a random peripheral blood glucose test at the screening visit (<200 mg/dl)
- Non-fluency in English or Spanish
- BMI <25.0 or ≥40.0 kg/m2
- >22 week's gestation
- multiple pregnancy
- current smoker
- present/prior obstetric conditions (preeclampsia, infections, placental abnormalities, uterine anomalies, congenital malformations, fetal chromosomal abnormalities)
- presence of any conditions that may dysregulate neuroendocrine, metabolic or cardiovascular function, such as diabetes, hepatic, renal, or autoimmune disorders
- current psychiatric disorders or undergoing treatment/taking psychiatric medications
- use of systemic/frequent corticosteroids or thyroid, lipid-lowering or anti-diabetic medications
- gestational diabetes mellitus or raised glucose result detected on the screening visit
- unwilling to eat the standard breakfast meal at each laboratory visit
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Postprandial glycemic response 2 weeks Intra-individual glycemic response (area-under-the-curve of glucose) to the standardized meal following exposure to either the psychosocial stress (TSST) or non-stress (control) task
- Secondary Outcome Measures
Name Time Method Postprandial lipid response 2 weeks Intra-individual lipid response (area-under-the-curve of triglycerides and free fatty acids) to the standardized meal following exposure to either the psychosocial stress (TSST) or non-stress (control) task
Postprandial inflammatory response 2 weeks Intra-individual lipid response (area-under-the-curve of inflammatory cytokines) to the standardized meal following exposure to either the psychosocial stress (TSST) or non-stress (control) task
Postprandial metabolic response to stress by meal type 3 hours Inter-individual difference in the glycemic/lipid/inflammatory AUC in response to the TSST between participants consuming the low GI compared to the high GI meal type
Trial Locations
- Locations (2)
University of California, Irvine
🇺🇸Irvine, California, United States
UCI Medical Center, University of California, Irvine
🇺🇸Orange, California, United States
University of California, Irvine🇺🇸Irvine, California, United States