Postprandial Response to Emotion-Diet Interactions in Pregnancy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pregnancy Related
- Sponsor
- University of California, Irvine
- Enrollment
- 113
- Locations
- 2
- Primary Endpoint
- Postprandial Glycemic Response With Stress Exposure
- Status
- Completed
- Last Updated
- 8 months ago
Overview
Brief Summary
This study will investigate how maternal emotional state following a controlled stress exposure in pregnancy influences blood glucose and insulin levels after eating a standardized meal, and whether the effects of emotional state on blood glucose and insulin is different after eating a healthy meal (low GI) compared to a less healthy meal (high GI).
Detailed Description
Maternal glucose-insulin homeostasis in pregnancy represents one of the most important physiological processes for maternal and child health outcomes. Although maternal diet is a key regulator of this process, its effects vary widely across individuals. Maternal stress could represent a moderator of considerable importance in this regard, yet little is known about the effects of stress on glycemic control in pregnancy and whether the effects of stress may vary as a function of diet quality. This project will investigate the effects of acute psychosocial stress exposure on the postprandial metabolic response to a meal of varying glycemic index (GI) among women with overweight/obesity in mid-pregnancy.
Investigators
Karen Lindsay
Assistant Professor
University of California, Irvine
Eligibility Criteria
Inclusion Criteria
- •English and/or Spanish speaking
- •18-22 week's gestation
- •Pre-pregnancy BMI 25.0-39.9 kg/m2
- •Singleton, intrauterine pregnancy
- •Non-smoker
- •Non-diabetic and normal result on a random peripheral blood glucose test at the screening visit (\<200 mg/dl)
Exclusion Criteria
- •Non-fluency in English or Spanish
- •BMI \<25.0 or ≥40.0 kg/m2
- •\>22 week's gestation
- •multiple pregnancy
- •current smoker
- •present/prior obstetric conditions (preeclampsia, infections, placental abnormalities, uterine anomalies, congenital malformations, fetal chromosomal abnormalities)
- •presence of any conditions that may dysregulate neuroendocrine, metabolic or cardiovascular function, such as diabetes, hepatic, renal, or autoimmune disorders
- •current psychiatric disorders or undergoing treatment/taking psychiatric medications
- •use of systemic/frequent corticosteroids or thyroid, lipid-lowering or anti-diabetic medications
- •gestational diabetes mellitus or raised glucose result detected on the screening visit
Outcomes
Primary Outcomes
Postprandial Glycemic Response With Stress Exposure
Time Frame: 2 weeks
Glycemic response (area-under-the-curve of glucose) to the assigned meal type during the visit with the psychosocial stress task (TSST)
Postprandial Glycemic Response Without Stress Exposure
Time Frame: 2 weeks
Glycemic response (glucose area-under-the-curve) to the assigned meal type during the visit with the non-stress control condition
Secondary Outcomes
- Postprandial Insulin Response With Stress Exposure(2 weeks)
- Postprandial Insulin Response Without Stress Exposure(2 weeks)