Prenatal Emotion-Diet Interactions and the Metabolic Response
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pregnancy Related
- Sponsor
- University of California, Irvine
- Enrollment
- 38
- Locations
- 1
- Primary Endpoint
- Difference in the glycemic response to the standardized meal +/- psychosocial challenge task
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
This study seeks to understand how a mother's emotional state in pregnancy influences her biological response to food intake.
Detailed Description
The purpose of this research study is to understand how a mother's emotional state in pregnancy influences her biological response to food intake. Natural variation in emotional and mental state is frequently experienced in daily life, including during pregnancy. While the investigators understand that a healthy diet is important in pregnancy for maintaining blood sugar levels and other metabolic factors within normal ranges for optimal development of the baby, less consideration is given to the health effects of a mother's mental state during pregnancy. It may even be possible that, regardless of what a woman eats or drinks, the way her body responds to food may differ according to her emotional or mental state. This research is particularly interested in understanding how the combination of maternal emotional state and diet influence metabolism in pregnancy. Thus, the aim of this study is to test whether and how an individual's emotional response to a mental challenge of varying complexity during pregnancy modifies the body's metabolic response to a standard breakfast.
Investigators
Karen Lindsay
Principal Investigator
University of California, Irvine
Eligibility Criteria
Inclusion Criteria
- •Age 18-40 years
- •Hispanic ethnicity
- •English and/or Spanish speaking
- •Multiparous
- •28-30 week's gestation
- •Pre-pregnancy BMI 25.0-34.9 kg/m2
- •Singleton, intrauterine pregnancy
- •Non-smoker
- •Non-diabetic and negative result on routine prenatal glucose challenge test (GCT)
Exclusion Criteria
- •BMI \<25.0 or ≥35.0 kg/m2
- •\>30 week's gestation
- •multiple pregnancy
- •nulliparous
- •present/prior obstetric risk conditions (hypertension, preeclampsia, infections, placental abnormalities)
- •current smoker
- •current psychiatric disorders or undergoing treatment/taking psychiatric medications
- •Use of systemic/frequent corticosteroids or thyroid meds
- •Diabetic or presence of other metabolic or neuroendocrine disorders
Outcomes
Primary Outcomes
Difference in the glycemic response to the standardized meal +/- psychosocial challenge task
Time Frame: 2 hours
Glycemic response (area-under-the-curve of glucose) to the standardized breakfast drink following exposure to either the psychosocial challenge (TSST) or non-challenge (placebo-TSST) task.
Secondary Outcomes
- Difference in the triglyceride response to the standardized meal +/- psychosocial challenge task(2 hours)
- Physiological stress response to the psychosocial challenge task(2 hours)