Navigated Brain Stimulation in Diagnosis of Minimally Conscious State
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 6
- 试验地点
- 2
- 主要终点
- MEP(motor evoked potential) parameter: latency
研究概览
简要总结
It has already been demonstrated that mental imagining of the complex motor act, such as limb lifting, can evoke the activation of the involved motor centres even if it doesn't result in movement due to paresis. Aim of the study: using the navigated brain stimulation system create a new diagnostic model for the differential diagnostics between the vegetative state and the minimally conscious state. If the investigators could get from patient the efferent motor response after a verbal command, his level of conscious should not be defined less than the minimally conscious state.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosed vegetative state
- •age 20-85
排除标准
- •oncological history
- •cardiac pacemakers and other metal implants
- •Modified Ashford Scale scores 3 and more
- •predisposing disease with motor neurologic impairment
结局指标
主要结局
MEP(motor evoked potential) parameter: latency
时间窗: within the first minute after a verbal command
次要结局
- MEP(motor evoked potential) parameter: amplitude(within the first minute after a verbal command)
- MEP(motor evoked potential) parameter: motor threshold(within the first minute after a verbal command)
- conscious state(within the first 6 months after NBS mapping)
研究者
Diana Vikulova
MD, neurologist, investigator
Clinical Institute of the Brain, Russia