Immunological Tolerance After Frequent Rabies Booster Vaccinations
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Rabies specific regulatory T cells
研究概览
简要总结
To study immunological tolerance effect after frequent rabies booster vaccination
详细描述
Previous studies had shown lower antibody titers among those who received frequent rabies booster vaccination, compared to ones who had got primary immunization. We study immunological cells i.e., regulatory T cell, regulatory B cell, T follicular helper cell, and cytokines in those who received frequent rabies booster vaccination.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
盲法说明
The serum samples from all participants would be labelled as the codes, of which the laboratory technicians could not access to the groups or other details of the participants.
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adults
- •Previously received rabies vaccination
排除标准
- •Had immunocompromised conditions
- •Received blood or blood product within 3 months
- •Received anti-malarial drugs
结局指标
主要结局
Rabies specific regulatory T cells
时间窗: Change from baseline of numbers of Rabies specific regulatory T cells before (baseline) and one month after receipt of rabies booster vaccination were compared between 2 arms
Rabies specific regulatory T cells are measured by flow cytometry method
Rabies specific regulatory B cells
时间窗: Change from baseline of numbers of Rabies specific regulatory B cells before (baseline) and one month after receipt of rabies booster vaccination were compared between 2 arms
Rabies specific regulatory B cells are measured by flow cytometry method
Rabies specific T follicular helper cells
时间窗: Change from baseline of numbers of Rabies specific T follicular helper cells before (baseline) and one month after receipt of rabies booster vaccination were compared between 2 arms
Rabies specific T follicular helper cells are measured by flow cytometry method
次要结局
- Rabies Neutralizing Antibody Titers (RNab)(before (baseline) and one month after receipt of rabies booster vaccination)
研究者
Suda Sibunruang
Principal Investigator
Queen Saovabha Memorial Institute