Effect of Maximal Strength Training in Relation to Age and Genes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 76
- 试验地点
- 3
- 主要终点
- Maximal muscle strength measured by 1 RM leg press in leg press machine
研究概览
简要总结
The study investigates the effect of maximal strength training on muscular strength and power in different age groups from 20 to 80 year old. It also relates the training adaptations to different known genes such as angiotensin I-converting enzyme (ACE) and Alpha-actinin-3 (ACTN3). Participants will complete an eight weeks, three times per week training intervention of maximal strength training with a pre-post design. In addition, blood samples will be collected for the analyses of genetic variances.
详细描述
Aim: The study aims to investigate the effect of age and genes on training adaptations to a maximal strength training intervention.
Methods: Participants will be recruited through invitations at work places and other community arenas. The investigators aim to recruit 10-15 subjects in each of the following age groups: 20-29, 30-39, 40-49, 50-59, 60-69 and 70-80 years of age. Both genders will be included. All age groups will be matched for age-related baseline maximal strength and distribution between the two genders. All participants will be checked via a health registration scheme, and excluded if contra indications for hard physical training or testing should appear. When in doubt, the projects physician will decide on inclusion or exclusion due to a thorough examination. Subjects will give a blood sample to be analyzed for known genes such as ACE and ACTN3. The intervention has a pre- post design. Tests of maximal strength and power will be conducted in a leg-press machine, using the protocol assessing one repetition maximum (1RM) previously described. Force and Power will be measured by the Muscle Lab system from Ergotest Tech. (Langesund, Norway). The intervention is an eight week, three times per week protocol, each training session consisting of a standardized warm-up, and 4 repetitions x 4 sets with an intensity of 4 repetition maximum (4RM) performed in the leg press machine.There will be a three minutes pause between sets. Participants will be given instructions and supervision.
Hypothesis
Maximal strength training adaptations will be affected by age and baseline maximal strength but not by gender or genetic variations.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adults 20 to 90 years old
排除标准
- •Contraindications to maximum strength training and testing
研究组 & 干预措施
Strength training
Strength training, 4 rep of 4RM x 4 sets in leg press.
干预措施: Strength training (Behavioral)
结局指标
主要结局
Maximal muscle strength measured by 1 RM leg press in leg press machine
时间窗: 8 weeks
次要结局
- Blood sample will be collected to assess gene types Alpha Actinin 3, Angiotensin Converting Enzyme, Angiotensinogen(8 weeks)
- rate of force development in leg press measured by MuscleLab (Ergotest Tech., Langesund Norway)(8 weeks)
- agility will be measured by counter movement jump using the MuscleLab system by Ergotest Tech. (Langesund, Norway)(8 weeks)