Functional Muscle-Bone Incongruity Index (FKUI): Combined Evaluation of Handgrip Strength, Total Hip Bone Mineral Density, and Lumbar-Hip Bone Mineral Density Discordance in Adults Undergoing DXA
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Functional Muscle-Bone Incongruity Index (FKUI)
研究概览
简要总结
The Functional Muscle-Bone Incongruity Index (FKUI) is a novel approach developed to evaluate the relationship between muscle function and bone health. This prospective observational study aims to investigate the clinical applicability of FKUI, which combines handgrip strength, total hip bone mineral density (BMD), and lumbar-hip BMD discordance. Approximately 200 adult participants undergoing routine DXA assessment will be enrolled. The study will examine whether the combined evaluation of muscle function and bone health parameters provides a more comprehensive assessment of musculoskeletal status than individual measures alone.
详细描述
This is a prospective, observational, single-center study evaluating adults undergoing routine DXA assessment in a Physical Medicine and Rehabilitation outpatient clinic. The study will investigate the clinical applicability of the Functional Muscle-Bone Incongruity Index (FKUI), a composite approach based on handgrip strength, total hip bone mineral density, and lumbar-hip bone mineral density discordance. No treatment or interventional procedure will be administered as part of the study. Handgrip strength will be measured using a calibrated hand dynamometer, and DXA-derived bone mineral density values will be recorded from routine clinical assessments. The study aims to determine whether the combined evaluation of muscle function and bone health parameters may provide a more comprehensive assessment of musculoskeletal status.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 years or older
- •Attendance at the Physical Medicine and Rehabilitation outpatient clinic
- •Scheduled to undergo routine bone mineral density assessment by DXA as part of clinical evaluation
- •Ability to perform handgrip strength testing
- •Availability of lumbar spine and total hip bone mineral density measurements suitable for analysis
- •Ability and willingness to provide written informed consent
排除标准
- •Exclusion Criteria:
- •Age younger than 18 years
- •Secondary causes of osteoporosis (e.g., hyperparathyroidism, Cushing syndrome, malignancy, or other conditions affecting bone metabolism)
- •History of metabolic bone disease
- •Major trauma or fracture within the previous 6 months
- •Upper extremity disorders that may significantly affect handgrip strength measurement (e.g., severe osteoarthritis, neurological disorders, major deformities)
- •DXA measurements that are technically inadequate or unsuitable for analysis
- •Refusal or inability to provide written informed consent
结局指标
主要结局
Functional Muscle-Bone Incongruity Index (FKUI)
时间窗: Baseline (at study enrollment)
Assessment of the clinical applicability of the Functional Muscle-Bone Incongruity Index (FKUI), a composite index based on handgrip strength, total hip bone mineral density, and lumbar-hip bone mineral density discordance.
次要结局
未报告次要终点
研究者
Dilek ün oguzhanasilturk
Physical Medicine and Rehabilitation Specialist
Kanuni Sultan Suleyman Training and Research Hospital