Optimum Menstrual Cycle Time for Endometrioma Excision
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 3
- 主要终点
- Determination of ovarian follicle damage via histological examination
研究概览
简要总结
This study evaluates the optimum day of menstrual period for the excision of endometriomas to minimize the damage of surgery to normal ovarian tissue. Patients will be grouped as follicular, ovulatory and luteal according to menstrual days. Ovarian damage will be evaluated with both pathologic examination and anti-mullerian hormone levels before and after the surgery.
详细描述
Endometriosis is a common gynecologic disease seen in about 10% of women in reproductive age. The most common site of endometriosis is overt. Cystic formation of ovarian endometriosis is called endometrioma (chocolate cyst). Definitive treatment of endometriomas is excision by laparoscopy. The disadvantage of this surgery is the removal of some of the normal ovarian follicles within cystectomy material. This procedure can damage the ovarian reserves with the treatment of endometriomas, which are already the cause of infertility, and lead to the conditions such as infertility or early menopause. It has been understood that the ovarian reserves of the patients who underwent endometrioma cystectomy with the decrease of the Anti-Mullerian Hormone values, which is an over reserve parameter.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •4 to 10 cm unilateral ovarian endometrioma
- •having clinically indication of laparoscopic ovarian endometrioma excision
排除标准
- •prior gynecologic surgery
- •prior abdominal surgery
- •additional operation in the same session
- •having the diagnosis of premature ovarian failure or ovarian insufficiency
- •having any diagnosis of malignancy
- •having diagnosis of a non-gynecologic chronicle disease
结局指标
主要结局
Determination of ovarian follicle damage via histological examination
时间窗: 5 days after the surgery
Histologic evaluation of the cystectomy excision material for health ovarian follicles
Change of anti-mullerian hormone level 6 months after surgery
时间窗: 6 months
Comparison of pre-operative and 6 months after surgery of anti-mullerian hormone levels
次要结局
未报告次要终点
研究者
Turgut Aydın
Assistant Professor
Acibadem University