Evaluation of Neuropsychological Effects of Drug-resistant Anterior Temporal Epilepsy and Anterior Temporal Lobectomy in Face Perception
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Scores obtained with Benton test by patients with anterior temporal epilepsy and matched control individuals
研究概览
简要总结
The purpose is to evaluate neuropsychological effects of anterior temporal epilepsy in face perception by comparison of performances of epileptic patients and control individuals, sex-, age- and socio-educational level-matched.
Secondary purposes are to prospectively evaluate neuropsychological impact of anterior temporal lobectomy performed for surgical treatment of anterior temporal epilepsy on face perception (exploratory study).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Informed consent
- •Affiliation to social security
- •Preliminary medical examination
- •PATIENTS WITH EPILEPSY:
- •Symptomatic drug-resistant anterior temporal epilepsy (confirmed with video-electroencephalography and magnetic resonance imaging and if necessary intracerebral SEEG exploration)
- •Patient needing anterior temporal lobectomy and undergoing pre-surgery conventional intercritical assessment for surgery decision
- •Nonverbal IQ ≥ 70 (WAIS-IV)
- •At least 6 successful VOSP tests (perception test)
排除标准
- •persons under legal protection or incapable to consent
- •Persons deprived of liberty by juridical or administrative decision
- •PATIENTS WITH EPILEPSY:
- •Sever visual disorders of neurological or ophthalmological origin
- •CONTROL INDIVIDUALS:
- •Psychiatric or neurological disorders
- •Important ophthalmological disorders
研究组 & 干预措施
Epilepsy
Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
干预措施: Mooney test (Other)
Epilepsy
Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
干预措施: Benton Face Recognition test (Other)
Epilepsy
Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
干预措施: Face inversion effect test (Other)
Epilepsy
Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
干预措施: Face composite effect test (Other)
Epilepsy
Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
干预措施: Cambridge Face Memory Test (Other)
Epilepsy
Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
干预措施: Matching different view test (Other)
Epilepsy
Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
干预措施: Memorizing and recognition of new faces test (Other)
Epilepsy
Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
干预措施: Memorizing and recognition of new objects test (Other)
Epilepsy
Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
干预措施: Recognition of celebrities and access to semantic information test (Other)
Epilepsy
Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy
干预措施: Lobectomy (Procedure)
Control
Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
干预措施: Mooney test (Other)
Control
Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
干预措施: Benton Face Recognition test (Other)
Control
Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
干预措施: Face inversion effect test (Other)
Control
Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
干预措施: Face composite effect test (Other)
Control
Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
干预措施: Cambridge Face Memory Test (Other)
Control
Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
干预措施: Matching different view test (Other)
Control
Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
干预措施: Memorizing and recognition of new faces test (Other)
Control
Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
干预措施: Memorizing and recognition of new objects test (Other)
Control
Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)
干预措施: Recognition of celebrities and access to semantic information test (Other)
结局指标
主要结局
Scores obtained with Benton test by patients with anterior temporal epilepsy and matched control individuals
时间窗: day 0
次要结局
- Change of scores obtained with Benton test by epilepsy patients before and after lobectomy and control individuals (only patients having undergone anterior temporal lobectomy and matched control individuals)(day 0 and after 24 to 30 months)