Neural Correlates of the Empathogenic and Affiliative Actions of Oxytocin
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 23
- 试验地点
- 1
- 主要终点
- Empathy ratings and their neural correlates
研究概览
简要总结
Mounting evidence indicates that the intranasal administration of the neuropeptide oxytocin has prosocial effects. However, the neural substrates of these effects are still unclear. The investigators hypothesized that a single dose administration of oxytocin should increase empathogenic and affiliative responses and that these effects are mediated by an increased insula activity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy male volunteers
- •In a heterosexual relationship
排除标准
- •Current or past psychiatric disease
- •Current or past physical illness
- •Psychoactive medication
- •Tobacco smokers
研究组 & 干预措施
Oxytocin
24 IU Oxytocin, intranasal application 45 min prior to the experiment
干预措施: Oxytocin (Drug)
Placebo
Intranasal application, sodium chloride solution, 3 puffs per nostril
干预措施: Placebo (Drug)
结局指标
主要结局
Empathy ratings and their neural correlates
时间窗: About one hour after the intranasal administration of oxytocin
All subjects are scanned while they view emotional and neutral faces and rate their empathy for these stimuli.
次要结局
- Neural correlates of pair-bonding(About one hour after the intranasal administration of oxytocin)
研究者
Rene Hurlemann
MSc MD PhD
University Hospital, Bonn