Role of Fibrocytes in the Bronchial Remodelling of Chronic Obstructive Pulmonary Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Increased number of peri-bronchial and blood circulating fibrocytes gradually in each stages of COPD and compared to control subjects.
研究概览
简要总结
Airway remodelling is an abnormal tissue repair following bronchial inflammation, which contributes to none reversible pathological features, such as bronchial and peri-bronchial fibrosis. It also influences the prognosis of Chronic Obstructive Pulmonary Disease (COPD) and its mechanisms remain largely unknown. The role of fibrocytes has been demonstrated in the pathophysiology of asthma, lung fibrosis or pulmonary hypertension. However, the recruitment of blood fibrocytes and their involvement in COPD airway remodelling remain unknown.
The main objective of the study is to analyse the distribution and quantify the number of the peri-bronchial and blood circulating fibrocytes in patients with different stages of COPD compared to control subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female aged more than 40 yr
- •Patient needed a thoracic surgery such as lobectomy for cancer or lung transplantation or lung reduction volume surgery.
- •COPD group: diagnostic of COPD and differentiation of the stage from 1 to 4 according to the GOLD guidelines.
- •Control group: subjects with normal lung function testing and no chronic symptoms (cough or expectoration). Subjects will be separated in 2 groups according to smoking history (Never smokers, smokers (former or current) and paired to patients according to age and sex.
- •with a written informed consent
排除标准
- •Subject without any social security or health insurance
- •Asthma, lung fibrosis or idiopathic pulmonary hypertension
- •Chronic viral infections (hepatitis, HIV)
- •Pregnant woman or breastfeeding
- •Subject included for cancer surgery with a Pn0 diagnosis not confirmed after the intervention.
结局指标
主要结局
Increased number of peri-bronchial and blood circulating fibrocytes gradually in each stages of COPD and compared to control subjects.
时间窗: Lung tissues and blood samples will be collected at inclusion visit during surgery (Day 0)
次要结局
- Correlation between plethysmography and the number of fibrocytes.(Assessed one year after inclusion visit (i.e. surgery date = Day 0))
- Characterization of fibrocytes: expression of chemokines receptors, Toll Like Receptors, HLA class II(Lung tissues and blood samples will be collected at inclusion visit during surgery (Day 0))
- Correlation between lung attenuation and the number of fibrocytes(Assessed one year after inclusion visit (i.e. surgery date =Day 0))