Effect of Male Ejaculation Frequency on Semen Parameters
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,500
- 试验地点
- 1
- 主要终点
- Effect of ejaculation frequency on sperm DNA fragmentation rate
研究概览
简要总结
The goal of this observational study is to determine whether the frequency of ejaculation in men had an effect on semen parameters.. The main questions it aims to answer are:
- question 1：Whether the frequency of ejaculation has an effect on semen parameters
- question 2：Whether the penultimate abstinence period has an effect on semen parameters
The participants were men who underwent semen examination in the andrology clinic of the Reproductive Center of the First Hospital of Jilin University. A brief medical history was collected from each volunteer, including demographic information, fertility history and as well as information regarding their general health.The focus of the investigation is the time of abstinence for this examination, the penultimate abstinence period, and the number of ejaculation since the last 1 month.
详细描述
The main subjects of this study were husbands who underwent semen examination, Including pre-conception, infertility, and his wife with a history of pregnancy loss. Before the examination, the basic information such as age, height, weight, smoking, drinking, infertility years, fertility and pregnancy history, marriage years, education, occupation and exclusion criteria have adverse effects on sperm were investigated.The focus of the investigation is the time of abstinence for this examination, the penultimate abstinence period, and the number of ejaculation since the last 1 month. According to World Health Organization standards, semen analysis requires abstinence for 48h to 7 days. Semen parameters were recorded, including sperm DNA fragmentation rate, sperm motility rate, total sperm count, sperm motility, and sperm morphology. The frequency of ejaculation was divided into four groups:(1)0-4 times/month;(2)5-8 times/month;(3) 8-12 times/month;(4) >12 times/month.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 22 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Normal ejaculation function, normal sexual life, masturbation can ejaculate
- •Male age between 22 and 45 years old.
- •According to World Health Organization standards, the semen examination time is within 48h to 7 days of abstinence.
排除标准
- •The man was diagnosed with extremely severe oligospermia (sperm concentration <1 million/ml) and azoospermia.
- •Identify the factors affecting semen parameters, long-term exposure to high temperature, long-term exposure to chemicals, heavy metals, radiation and other toxic and harmful substances, orchitis/epididymitis, cryptorchidism, radiotherapy and chemotherapy treatment, and taking drugs to improve sperm within three months
结局指标
主要结局
Effect of ejaculation frequency on sperm DNA fragmentation rate
时间窗: 6 months
The subjects abstained for 3-7 days and masturbated to collect semen for measurement of sperm DNA fragment rate. Survey the basic information of the subjects and their frequency of ejaculation in the past month.The frequency of ejaculation was divided into four groups:(1) 0-4 times/month; (2) 5-8 times/month; (3) 8-12 times/month; (4) \>12 times/month. The outcome was to compare whether there were differences in semen parameters between the groups
Effect of ejaculation frequency on sperm motility rate
时间窗: 6 months
The subjects abstained for 3-7 days and masturbated to collect semen for measurement of sperm motility rate. Survey the basic information of the subjects and their frequency of ejaculation in the past month. The frequency of ejaculation was divided into four groups:(1) 0-4 times/month; (2) 5-8 times/month; (3) 8-12 times/month; (4) \>12 times/month. The outcome was to compare whether there were differences in semen parameters between the groups
Effect of ejaculation frequency on total sperm count
时间窗: 6 months
The subjects abstained for 3-7 days and masturbated to collect semen for measurement of total sperm count. Survey the basic information of the subjects and their frequency of ejaculation in the past month. The frequency of ejaculation was divided into four groups:(1) 0-4 times/month; (2) 5-8 times/month; (3) 8-12 times/month; (4) \>12 times/month. The outcome was to compare whether there were differences in semen parameters between the groups
Effect of ejaculation frequency on sperm vitality rate
时间窗: 6 months
The subjects abstained for 3-7 days and masturbated to collect semen for measurement of sperm vitality rate. Survey the basic information of the subjects and their frequency of ejaculation in the past month. The frequency of ejaculation was divided into four groups:(1) 0-4 times/month; (2) 5-8 times/month; (3) 8-12 times/month; (4) \>12 times/month. The outcome was to compare whether there were differences in semen parameters between the groups
Effect of ejaculation frequency on sperm morphology
时间窗: 6 months
The subjects abstained for 3-7 days and masturbated to collect semen for measurement of sperm morphology. Survey the basic information of the subjects and their frequency of ejaculation in the past month. The frequency of ejaculation was divided into four groups:(1) 0-4 times/month; (2) 5-8 times/month; (3) 8-12 times/month; (4) \>12 times/month. The outcome was to compare whether there were differences in semen parameters between the groups
次要结局
- Effect of the penultimate abstinence period on DNA fragmentation rate(6 months)